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Pharmacological Effects of Verticine: Current Status
Verticine is the major bioactive constituent of Fritillaria as a kind of Traditional Chinese Medicine. Pharmacological researches have reported various benefits of verticine, including anticancer, anti-inflammatory, protecting against acute lung injury, tracheobronchial relaxation, antitussive, expe...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431433/ https://www.ncbi.nlm.nih.gov/pubmed/30956677 http://dx.doi.org/10.1155/2019/2394605 |
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author | Yin, Zhenhua Zhang, Juanjuan Guo, Qingfeng Chen, Lin Zhang, Wei Kang, Wenyi |
author_facet | Yin, Zhenhua Zhang, Juanjuan Guo, Qingfeng Chen, Lin Zhang, Wei Kang, Wenyi |
author_sort | Yin, Zhenhua |
collection | PubMed |
description | Verticine is the major bioactive constituent of Fritillaria as a kind of Traditional Chinese Medicine. Pharmacological researches have reported various benefits of verticine, including anticancer, anti-inflammatory, protecting against acute lung injury, tracheobronchial relaxation, antitussive, expectorant, sedative, and analgesic activities, in addition to inhibiting proliferation of cultured orbital fibroblast, angiotensin converting enzyme (ACE), and acetylcholinesterase (AChE) and inhibiting hERG potassium channels. The underlying mechanisms of verticine are still under investigation. This review will comprehensively summarize the metabolism, biological activities, and possible mechanism of verticine. |
format | Online Article Text |
id | pubmed-6431433 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-64314332019-04-07 Pharmacological Effects of Verticine: Current Status Yin, Zhenhua Zhang, Juanjuan Guo, Qingfeng Chen, Lin Zhang, Wei Kang, Wenyi Evid Based Complement Alternat Med Review Article Verticine is the major bioactive constituent of Fritillaria as a kind of Traditional Chinese Medicine. Pharmacological researches have reported various benefits of verticine, including anticancer, anti-inflammatory, protecting against acute lung injury, tracheobronchial relaxation, antitussive, expectorant, sedative, and analgesic activities, in addition to inhibiting proliferation of cultured orbital fibroblast, angiotensin converting enzyme (ACE), and acetylcholinesterase (AChE) and inhibiting hERG potassium channels. The underlying mechanisms of verticine are still under investigation. This review will comprehensively summarize the metabolism, biological activities, and possible mechanism of verticine. Hindawi 2019-03-07 /pmc/articles/PMC6431433/ /pubmed/30956677 http://dx.doi.org/10.1155/2019/2394605 Text en Copyright © 2019 Zhenhua Yin et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Yin, Zhenhua Zhang, Juanjuan Guo, Qingfeng Chen, Lin Zhang, Wei Kang, Wenyi Pharmacological Effects of Verticine: Current Status |
title | Pharmacological Effects of Verticine: Current Status |
title_full | Pharmacological Effects of Verticine: Current Status |
title_fullStr | Pharmacological Effects of Verticine: Current Status |
title_full_unstemmed | Pharmacological Effects of Verticine: Current Status |
title_short | Pharmacological Effects of Verticine: Current Status |
title_sort | pharmacological effects of verticine: current status |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431433/ https://www.ncbi.nlm.nih.gov/pubmed/30956677 http://dx.doi.org/10.1155/2019/2394605 |
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