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Pharmacological Effects of Verticine: Current Status

Verticine is the major bioactive constituent of Fritillaria as a kind of Traditional Chinese Medicine. Pharmacological researches have reported various benefits of verticine, including anticancer, anti-inflammatory, protecting against acute lung injury, tracheobronchial relaxation, antitussive, expe...

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Detalles Bibliográficos
Autores principales: Yin, Zhenhua, Zhang, Juanjuan, Guo, Qingfeng, Chen, Lin, Zhang, Wei, Kang, Wenyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431433/
https://www.ncbi.nlm.nih.gov/pubmed/30956677
http://dx.doi.org/10.1155/2019/2394605
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author Yin, Zhenhua
Zhang, Juanjuan
Guo, Qingfeng
Chen, Lin
Zhang, Wei
Kang, Wenyi
author_facet Yin, Zhenhua
Zhang, Juanjuan
Guo, Qingfeng
Chen, Lin
Zhang, Wei
Kang, Wenyi
author_sort Yin, Zhenhua
collection PubMed
description Verticine is the major bioactive constituent of Fritillaria as a kind of Traditional Chinese Medicine. Pharmacological researches have reported various benefits of verticine, including anticancer, anti-inflammatory, protecting against acute lung injury, tracheobronchial relaxation, antitussive, expectorant, sedative, and analgesic activities, in addition to inhibiting proliferation of cultured orbital fibroblast, angiotensin converting enzyme (ACE), and acetylcholinesterase (AChE) and inhibiting hERG potassium channels. The underlying mechanisms of verticine are still under investigation. This review will comprehensively summarize the metabolism, biological activities, and possible mechanism of verticine.
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spelling pubmed-64314332019-04-07 Pharmacological Effects of Verticine: Current Status Yin, Zhenhua Zhang, Juanjuan Guo, Qingfeng Chen, Lin Zhang, Wei Kang, Wenyi Evid Based Complement Alternat Med Review Article Verticine is the major bioactive constituent of Fritillaria as a kind of Traditional Chinese Medicine. Pharmacological researches have reported various benefits of verticine, including anticancer, anti-inflammatory, protecting against acute lung injury, tracheobronchial relaxation, antitussive, expectorant, sedative, and analgesic activities, in addition to inhibiting proliferation of cultured orbital fibroblast, angiotensin converting enzyme (ACE), and acetylcholinesterase (AChE) and inhibiting hERG potassium channels. The underlying mechanisms of verticine are still under investigation. This review will comprehensively summarize the metabolism, biological activities, and possible mechanism of verticine. Hindawi 2019-03-07 /pmc/articles/PMC6431433/ /pubmed/30956677 http://dx.doi.org/10.1155/2019/2394605 Text en Copyright © 2019 Zhenhua Yin et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Yin, Zhenhua
Zhang, Juanjuan
Guo, Qingfeng
Chen, Lin
Zhang, Wei
Kang, Wenyi
Pharmacological Effects of Verticine: Current Status
title Pharmacological Effects of Verticine: Current Status
title_full Pharmacological Effects of Verticine: Current Status
title_fullStr Pharmacological Effects of Verticine: Current Status
title_full_unstemmed Pharmacological Effects of Verticine: Current Status
title_short Pharmacological Effects of Verticine: Current Status
title_sort pharmacological effects of verticine: current status
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431433/
https://www.ncbi.nlm.nih.gov/pubmed/30956677
http://dx.doi.org/10.1155/2019/2394605
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