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Orchestration of Adaptive T Cell Responses by Neutrophil Granule Contents
Neutrophils are the most abundant leukocytes in peripheral blood and respond rapidly to danger, infiltrating tissues within minutes of infectious or sterile injury. Neutrophils were long thought of as simple killers, but now we recognise them as responsive cells able to adapt to inflammation and orc...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431490/ https://www.ncbi.nlm.nih.gov/pubmed/30983883 http://dx.doi.org/10.1155/2019/8968943 |
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author | Minns, Danielle Smith, Katie Jane Findlay, Emily Gwyer |
author_facet | Minns, Danielle Smith, Katie Jane Findlay, Emily Gwyer |
author_sort | Minns, Danielle |
collection | PubMed |
description | Neutrophils are the most abundant leukocytes in peripheral blood and respond rapidly to danger, infiltrating tissues within minutes of infectious or sterile injury. Neutrophils were long thought of as simple killers, but now we recognise them as responsive cells able to adapt to inflammation and orchestrate subsequent events with some sophistication. Here, we discuss how these rapid responders release mediators which influence later adaptive T cell immunity through influences on DC priming and directly on the T cells themselves. We consider how the release of granule contents by neutrophils—through NETosis or degranulation—is one way in which the innate immune system directs the phenotype of the adaptive immune response. |
format | Online Article Text |
id | pubmed-6431490 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-64314902019-04-14 Orchestration of Adaptive T Cell Responses by Neutrophil Granule Contents Minns, Danielle Smith, Katie Jane Findlay, Emily Gwyer Mediators Inflamm Review Article Neutrophils are the most abundant leukocytes in peripheral blood and respond rapidly to danger, infiltrating tissues within minutes of infectious or sterile injury. Neutrophils were long thought of as simple killers, but now we recognise them as responsive cells able to adapt to inflammation and orchestrate subsequent events with some sophistication. Here, we discuss how these rapid responders release mediators which influence later adaptive T cell immunity through influences on DC priming and directly on the T cells themselves. We consider how the release of granule contents by neutrophils—through NETosis or degranulation—is one way in which the innate immune system directs the phenotype of the adaptive immune response. Hindawi 2019-03-10 /pmc/articles/PMC6431490/ /pubmed/30983883 http://dx.doi.org/10.1155/2019/8968943 Text en Copyright © 2019 Danielle Minns et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Minns, Danielle Smith, Katie Jane Findlay, Emily Gwyer Orchestration of Adaptive T Cell Responses by Neutrophil Granule Contents |
title | Orchestration of Adaptive T Cell Responses by Neutrophil Granule Contents |
title_full | Orchestration of Adaptive T Cell Responses by Neutrophil Granule Contents |
title_fullStr | Orchestration of Adaptive T Cell Responses by Neutrophil Granule Contents |
title_full_unstemmed | Orchestration of Adaptive T Cell Responses by Neutrophil Granule Contents |
title_short | Orchestration of Adaptive T Cell Responses by Neutrophil Granule Contents |
title_sort | orchestration of adaptive t cell responses by neutrophil granule contents |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431490/ https://www.ncbi.nlm.nih.gov/pubmed/30983883 http://dx.doi.org/10.1155/2019/8968943 |
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