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Concise Review: The Endothelial Cell Extracellular Matrix Regulates Tissue Homeostasis and Repair
All tissues are surrounded by a mixture of noncellular matrix components, that not only provide physical and mechanical support to cells, but also mediate biochemical signaling between cells. The extracellular matrix (ECM) of endothelial cells, also known as the perivascular matrix, forms an organ s...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431685/ https://www.ncbi.nlm.nih.gov/pubmed/30537441 http://dx.doi.org/10.1002/sctm.18-0155 |
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author | Witjas, Franca M. R. van den Berg, Bernard M. van den Berg, Cathelijne W. Engelse, Marten A. Rabelink, Ton J. |
author_facet | Witjas, Franca M. R. van den Berg, Bernard M. van den Berg, Cathelijne W. Engelse, Marten A. Rabelink, Ton J. |
author_sort | Witjas, Franca M. R. |
collection | PubMed |
description | All tissues are surrounded by a mixture of noncellular matrix components, that not only provide physical and mechanical support to cells, but also mediate biochemical signaling between cells. The extracellular matrix (ECM) of endothelial cells, also known as the perivascular matrix, forms an organ specific vascular niche that orchestrates mechano‐, growth factor, and angiocrine signaling required for tissue homeostasis and organ repair. This concise review describes how this perivascular ECM functions as a signaling platform and how this knowledge can impact the field of regenerative medicine, for example, when designing artificial matrices or using decellularized scaffolds from organs. stem cells translational medicine 2019;8:375–382 |
format | Online Article Text |
id | pubmed-6431685 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64316852019-04-05 Concise Review: The Endothelial Cell Extracellular Matrix Regulates Tissue Homeostasis and Repair Witjas, Franca M. R. van den Berg, Bernard M. van den Berg, Cathelijne W. Engelse, Marten A. Rabelink, Ton J. Stem Cells Transl Med Tissue Engineering and Regenerative Medicine All tissues are surrounded by a mixture of noncellular matrix components, that not only provide physical and mechanical support to cells, but also mediate biochemical signaling between cells. The extracellular matrix (ECM) of endothelial cells, also known as the perivascular matrix, forms an organ specific vascular niche that orchestrates mechano‐, growth factor, and angiocrine signaling required for tissue homeostasis and organ repair. This concise review describes how this perivascular ECM functions as a signaling platform and how this knowledge can impact the field of regenerative medicine, for example, when designing artificial matrices or using decellularized scaffolds from organs. stem cells translational medicine 2019;8:375–382 John Wiley & Sons, Inc. 2018-12-11 /pmc/articles/PMC6431685/ /pubmed/30537441 http://dx.doi.org/10.1002/sctm.18-0155 Text en © 2018 The Authors stem cells translational medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Tissue Engineering and Regenerative Medicine Witjas, Franca M. R. van den Berg, Bernard M. van den Berg, Cathelijne W. Engelse, Marten A. Rabelink, Ton J. Concise Review: The Endothelial Cell Extracellular Matrix Regulates Tissue Homeostasis and Repair |
title | Concise Review: The Endothelial Cell Extracellular Matrix Regulates Tissue Homeostasis and Repair |
title_full | Concise Review: The Endothelial Cell Extracellular Matrix Regulates Tissue Homeostasis and Repair |
title_fullStr | Concise Review: The Endothelial Cell Extracellular Matrix Regulates Tissue Homeostasis and Repair |
title_full_unstemmed | Concise Review: The Endothelial Cell Extracellular Matrix Regulates Tissue Homeostasis and Repair |
title_short | Concise Review: The Endothelial Cell Extracellular Matrix Regulates Tissue Homeostasis and Repair |
title_sort | concise review: the endothelial cell extracellular matrix regulates tissue homeostasis and repair |
topic | Tissue Engineering and Regenerative Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431685/ https://www.ncbi.nlm.nih.gov/pubmed/30537441 http://dx.doi.org/10.1002/sctm.18-0155 |
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