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Concise Review: The Endothelial Cell Extracellular Matrix Regulates Tissue Homeostasis and Repair

All tissues are surrounded by a mixture of noncellular matrix components, that not only provide physical and mechanical support to cells, but also mediate biochemical signaling between cells. The extracellular matrix (ECM) of endothelial cells, also known as the perivascular matrix, forms an organ s...

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Autores principales: Witjas, Franca M. R., van den Berg, Bernard M., van den Berg, Cathelijne W., Engelse, Marten A., Rabelink, Ton J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431685/
https://www.ncbi.nlm.nih.gov/pubmed/30537441
http://dx.doi.org/10.1002/sctm.18-0155
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author Witjas, Franca M. R.
van den Berg, Bernard M.
van den Berg, Cathelijne W.
Engelse, Marten A.
Rabelink, Ton J.
author_facet Witjas, Franca M. R.
van den Berg, Bernard M.
van den Berg, Cathelijne W.
Engelse, Marten A.
Rabelink, Ton J.
author_sort Witjas, Franca M. R.
collection PubMed
description All tissues are surrounded by a mixture of noncellular matrix components, that not only provide physical and mechanical support to cells, but also mediate biochemical signaling between cells. The extracellular matrix (ECM) of endothelial cells, also known as the perivascular matrix, forms an organ specific vascular niche that orchestrates mechano‐, growth factor, and angiocrine signaling required for tissue homeostasis and organ repair. This concise review describes how this perivascular ECM functions as a signaling platform and how this knowledge can impact the field of regenerative medicine, for example, when designing artificial matrices or using decellularized scaffolds from organs. stem cells translational medicine 2019;8:375–382
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spelling pubmed-64316852019-04-05 Concise Review: The Endothelial Cell Extracellular Matrix Regulates Tissue Homeostasis and Repair Witjas, Franca M. R. van den Berg, Bernard M. van den Berg, Cathelijne W. Engelse, Marten A. Rabelink, Ton J. Stem Cells Transl Med Tissue Engineering and Regenerative Medicine All tissues are surrounded by a mixture of noncellular matrix components, that not only provide physical and mechanical support to cells, but also mediate biochemical signaling between cells. The extracellular matrix (ECM) of endothelial cells, also known as the perivascular matrix, forms an organ specific vascular niche that orchestrates mechano‐, growth factor, and angiocrine signaling required for tissue homeostasis and organ repair. This concise review describes how this perivascular ECM functions as a signaling platform and how this knowledge can impact the field of regenerative medicine, for example, when designing artificial matrices or using decellularized scaffolds from organs. stem cells translational medicine 2019;8:375–382 John Wiley & Sons, Inc. 2018-12-11 /pmc/articles/PMC6431685/ /pubmed/30537441 http://dx.doi.org/10.1002/sctm.18-0155 Text en © 2018 The Authors stem cells translational medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Tissue Engineering and Regenerative Medicine
Witjas, Franca M. R.
van den Berg, Bernard M.
van den Berg, Cathelijne W.
Engelse, Marten A.
Rabelink, Ton J.
Concise Review: The Endothelial Cell Extracellular Matrix Regulates Tissue Homeostasis and Repair
title Concise Review: The Endothelial Cell Extracellular Matrix Regulates Tissue Homeostasis and Repair
title_full Concise Review: The Endothelial Cell Extracellular Matrix Regulates Tissue Homeostasis and Repair
title_fullStr Concise Review: The Endothelial Cell Extracellular Matrix Regulates Tissue Homeostasis and Repair
title_full_unstemmed Concise Review: The Endothelial Cell Extracellular Matrix Regulates Tissue Homeostasis and Repair
title_short Concise Review: The Endothelial Cell Extracellular Matrix Regulates Tissue Homeostasis and Repair
title_sort concise review: the endothelial cell extracellular matrix regulates tissue homeostasis and repair
topic Tissue Engineering and Regenerative Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431685/
https://www.ncbi.nlm.nih.gov/pubmed/30537441
http://dx.doi.org/10.1002/sctm.18-0155
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