A Facile Approach for Fabrication of Core-Shell Magnetic Molecularly Imprinted Nanospheres towards Hypericin

By taking advantage of the self-polymerization of dopamine on the surface of magnetic nanospheres in weak alkaline Tris-HCl buffer solution, a facile approach was established to fabricate core-shell magnetic molecularly imprinted nanospheres towards hypericin (Fe(3)O(4)@PDA/Hyp NSs), via a surface m...

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Detalles Bibliográficos
Autores principales: Cheng, Wenxia, Fan, Fengfeng, Zhang, Ying, Pei, Zhichao, Wang, Wenji, Pei, Yuxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431851/
https://www.ncbi.nlm.nih.gov/pubmed/30970815
http://dx.doi.org/10.3390/polym9040135
Descripción
Sumario:By taking advantage of the self-polymerization of dopamine on the surface of magnetic nanospheres in weak alkaline Tris-HCl buffer solution, a facile approach was established to fabricate core-shell magnetic molecularly imprinted nanospheres towards hypericin (Fe(3)O(4)@PDA/Hyp NSs), via a surface molecular imprinting technique. The Fe(3)O(4)@PDA/Hyp NSs were characterized by FTIR, TEM, DLS, and BET methods, respectively. The reaction conditions for adsorption capacity and selectivity towards hypericin were optimized, and the Fe(3)O(4)@PDA/Hyp NSs synthesized under the optimized conditions showed a high adsorption capacity (Q = 18.28 mg/g) towards hypericin. The selectivity factors of Fe(3)O(4)@PDA/Hyp NSs were about 1.92 and 3.55 towards protohypericin and emodin, respectively. In addition, the approach established in this work showed good reproducibility for fabrication of Fe(3)O(4)@PDA/Hyp.

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