Smart Poly(imidazoyl-l-lysine): Synthesis and Reversible Helix-to-Coil Transition at Neutral pH

Polypeptide polymers can adopt natural protein secondary structures such as α-helices or β-sheets, and this unique feature is at the origin of some intriguing physico–chemical properties. In this work, we present how side chain imidazoylation of a poly(l-lysine) scaffold affords the preparation of p...

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Autores principales: Piedra-Arroni, Estefania, Makni, Fatma, Severac, Laura, Stigliani, Jean-Luc, Pratviel, Geneviève, Bonduelle, Colin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432093/
https://www.ncbi.nlm.nih.gov/pubmed/30970954
http://dx.doi.org/10.3390/polym9070276
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author Piedra-Arroni, Estefania
Makni, Fatma
Severac, Laura
Stigliani, Jean-Luc
Pratviel, Geneviève
Bonduelle, Colin
author_facet Piedra-Arroni, Estefania
Makni, Fatma
Severac, Laura
Stigliani, Jean-Luc
Pratviel, Geneviève
Bonduelle, Colin
author_sort Piedra-Arroni, Estefania
collection PubMed
description Polypeptide polymers can adopt natural protein secondary structures such as α-helices or β-sheets, and this unique feature is at the origin of some intriguing physico–chemical properties. In this work, we present how side chain imidazoylation of a poly(l-lysine) scaffold affords the preparation of poly(histidine) counterparts exhibiting α-helix conformation. This structuring behavior is reversible and can be controlled by means of pH and or temperature changes.
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spelling pubmed-64320932019-04-02 Smart Poly(imidazoyl-l-lysine): Synthesis and Reversible Helix-to-Coil Transition at Neutral pH Piedra-Arroni, Estefania Makni, Fatma Severac, Laura Stigliani, Jean-Luc Pratviel, Geneviève Bonduelle, Colin Polymers (Basel) Article Polypeptide polymers can adopt natural protein secondary structures such as α-helices or β-sheets, and this unique feature is at the origin of some intriguing physico–chemical properties. In this work, we present how side chain imidazoylation of a poly(l-lysine) scaffold affords the preparation of poly(histidine) counterparts exhibiting α-helix conformation. This structuring behavior is reversible and can be controlled by means of pH and or temperature changes. MDPI 2017-07-11 /pmc/articles/PMC6432093/ /pubmed/30970954 http://dx.doi.org/10.3390/polym9070276 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Piedra-Arroni, Estefania
Makni, Fatma
Severac, Laura
Stigliani, Jean-Luc
Pratviel, Geneviève
Bonduelle, Colin
Smart Poly(imidazoyl-l-lysine): Synthesis and Reversible Helix-to-Coil Transition at Neutral pH
title Smart Poly(imidazoyl-l-lysine): Synthesis and Reversible Helix-to-Coil Transition at Neutral pH
title_full Smart Poly(imidazoyl-l-lysine): Synthesis and Reversible Helix-to-Coil Transition at Neutral pH
title_fullStr Smart Poly(imidazoyl-l-lysine): Synthesis and Reversible Helix-to-Coil Transition at Neutral pH
title_full_unstemmed Smart Poly(imidazoyl-l-lysine): Synthesis and Reversible Helix-to-Coil Transition at Neutral pH
title_short Smart Poly(imidazoyl-l-lysine): Synthesis and Reversible Helix-to-Coil Transition at Neutral pH
title_sort smart poly(imidazoyl-l-lysine): synthesis and reversible helix-to-coil transition at neutral ph
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432093/
https://www.ncbi.nlm.nih.gov/pubmed/30970954
http://dx.doi.org/10.3390/polym9070276
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