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The Synthesis of Backbone Thermo and pH Responsive Hyperbranched Poly(Bis(N,N-Propyl Acryl Amide))s by RAFT

Hyperbranched poly(methylene-bis-acrylamide), poly(bis(N,N-propyl acryl amide)) (HPNPAM) and poly(bis(N,N-butyl acryl amide)) were synthesized by reversible addition-fragmentation chain transfer polymerization. HPNPAMs showed lower critical solution temperature (LCST) due to an appropriate ratio bet...

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Autores principales: Zhou, Shijiao, Zhang, Dongxin, Bai, Libin, Zhao, Jing, Wu, Yonggang, Zhao, Hongchi, Ba, Xinwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432253/
https://www.ncbi.nlm.nih.gov/pubmed/30979223
http://dx.doi.org/10.3390/polym8040135
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author Zhou, Shijiao
Zhang, Dongxin
Bai, Libin
Zhao, Jing
Wu, Yonggang
Zhao, Hongchi
Ba, Xinwu
author_facet Zhou, Shijiao
Zhang, Dongxin
Bai, Libin
Zhao, Jing
Wu, Yonggang
Zhao, Hongchi
Ba, Xinwu
author_sort Zhou, Shijiao
collection PubMed
description Hyperbranched poly(methylene-bis-acrylamide), poly(bis(N,N-propyl acryl amide)) (HPNPAM) and poly(bis(N,N-butyl acryl amide)) were synthesized by reversible addition-fragmentation chain transfer polymerization. HPNPAMs showed lower critical solution temperature (LCST) due to an appropriate ratio between hydrophilic and hydrophobic groups. The effects of reaction conditions on polymerization were investigated in detail. The structure of HPNPAM was characterized by (1)H NMR, FT-IR, Muti detector-size exclusion chromatography (MDSEC) and Ultravioletvisble (UV-Vis). The α value reached 0.20 and DB was 90%, indicating HPNPAMs with compact topology structure were successfully prepared. LCSTs were tuned by M(w) and the pH value of the solution. The change of molecular size was assayed by dynamic light scattering and scanning electron microscope. These results indicated that the stable uniform nanomicelles were destroyed and macromolecules aggregated together, forming large particles as temperature exceeded LCST. In addition, after the cells were incubated for 24 h, the cell viability reached 80%, which confirmed this new dual responsive HPNPAM had low cytotoxicity.
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spelling pubmed-64322532019-04-02 The Synthesis of Backbone Thermo and pH Responsive Hyperbranched Poly(Bis(N,N-Propyl Acryl Amide))s by RAFT Zhou, Shijiao Zhang, Dongxin Bai, Libin Zhao, Jing Wu, Yonggang Zhao, Hongchi Ba, Xinwu Polymers (Basel) Article Hyperbranched poly(methylene-bis-acrylamide), poly(bis(N,N-propyl acryl amide)) (HPNPAM) and poly(bis(N,N-butyl acryl amide)) were synthesized by reversible addition-fragmentation chain transfer polymerization. HPNPAMs showed lower critical solution temperature (LCST) due to an appropriate ratio between hydrophilic and hydrophobic groups. The effects of reaction conditions on polymerization were investigated in detail. The structure of HPNPAM was characterized by (1)H NMR, FT-IR, Muti detector-size exclusion chromatography (MDSEC) and Ultravioletvisble (UV-Vis). The α value reached 0.20 and DB was 90%, indicating HPNPAMs with compact topology structure were successfully prepared. LCSTs were tuned by M(w) and the pH value of the solution. The change of molecular size was assayed by dynamic light scattering and scanning electron microscope. These results indicated that the stable uniform nanomicelles were destroyed and macromolecules aggregated together, forming large particles as temperature exceeded LCST. In addition, after the cells were incubated for 24 h, the cell viability reached 80%, which confirmed this new dual responsive HPNPAM had low cytotoxicity. MDPI 2016-04-08 /pmc/articles/PMC6432253/ /pubmed/30979223 http://dx.doi.org/10.3390/polym8040135 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhou, Shijiao
Zhang, Dongxin
Bai, Libin
Zhao, Jing
Wu, Yonggang
Zhao, Hongchi
Ba, Xinwu
The Synthesis of Backbone Thermo and pH Responsive Hyperbranched Poly(Bis(N,N-Propyl Acryl Amide))s by RAFT
title The Synthesis of Backbone Thermo and pH Responsive Hyperbranched Poly(Bis(N,N-Propyl Acryl Amide))s by RAFT
title_full The Synthesis of Backbone Thermo and pH Responsive Hyperbranched Poly(Bis(N,N-Propyl Acryl Amide))s by RAFT
title_fullStr The Synthesis of Backbone Thermo and pH Responsive Hyperbranched Poly(Bis(N,N-Propyl Acryl Amide))s by RAFT
title_full_unstemmed The Synthesis of Backbone Thermo and pH Responsive Hyperbranched Poly(Bis(N,N-Propyl Acryl Amide))s by RAFT
title_short The Synthesis of Backbone Thermo and pH Responsive Hyperbranched Poly(Bis(N,N-Propyl Acryl Amide))s by RAFT
title_sort synthesis of backbone thermo and ph responsive hyperbranched poly(bis(n,n-propyl acryl amide))s by raft
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432253/
https://www.ncbi.nlm.nih.gov/pubmed/30979223
http://dx.doi.org/10.3390/polym8040135
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