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The Synthesis of Backbone Thermo and pH Responsive Hyperbranched Poly(Bis(N,N-Propyl Acryl Amide))s by RAFT
Hyperbranched poly(methylene-bis-acrylamide), poly(bis(N,N-propyl acryl amide)) (HPNPAM) and poly(bis(N,N-butyl acryl amide)) were synthesized by reversible addition-fragmentation chain transfer polymerization. HPNPAMs showed lower critical solution temperature (LCST) due to an appropriate ratio bet...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432253/ https://www.ncbi.nlm.nih.gov/pubmed/30979223 http://dx.doi.org/10.3390/polym8040135 |
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author | Zhou, Shijiao Zhang, Dongxin Bai, Libin Zhao, Jing Wu, Yonggang Zhao, Hongchi Ba, Xinwu |
author_facet | Zhou, Shijiao Zhang, Dongxin Bai, Libin Zhao, Jing Wu, Yonggang Zhao, Hongchi Ba, Xinwu |
author_sort | Zhou, Shijiao |
collection | PubMed |
description | Hyperbranched poly(methylene-bis-acrylamide), poly(bis(N,N-propyl acryl amide)) (HPNPAM) and poly(bis(N,N-butyl acryl amide)) were synthesized by reversible addition-fragmentation chain transfer polymerization. HPNPAMs showed lower critical solution temperature (LCST) due to an appropriate ratio between hydrophilic and hydrophobic groups. The effects of reaction conditions on polymerization were investigated in detail. The structure of HPNPAM was characterized by (1)H NMR, FT-IR, Muti detector-size exclusion chromatography (MDSEC) and Ultravioletvisble (UV-Vis). The α value reached 0.20 and DB was 90%, indicating HPNPAMs with compact topology structure were successfully prepared. LCSTs were tuned by M(w) and the pH value of the solution. The change of molecular size was assayed by dynamic light scattering and scanning electron microscope. These results indicated that the stable uniform nanomicelles were destroyed and macromolecules aggregated together, forming large particles as temperature exceeded LCST. In addition, after the cells were incubated for 24 h, the cell viability reached 80%, which confirmed this new dual responsive HPNPAM had low cytotoxicity. |
format | Online Article Text |
id | pubmed-6432253 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64322532019-04-02 The Synthesis of Backbone Thermo and pH Responsive Hyperbranched Poly(Bis(N,N-Propyl Acryl Amide))s by RAFT Zhou, Shijiao Zhang, Dongxin Bai, Libin Zhao, Jing Wu, Yonggang Zhao, Hongchi Ba, Xinwu Polymers (Basel) Article Hyperbranched poly(methylene-bis-acrylamide), poly(bis(N,N-propyl acryl amide)) (HPNPAM) and poly(bis(N,N-butyl acryl amide)) were synthesized by reversible addition-fragmentation chain transfer polymerization. HPNPAMs showed lower critical solution temperature (LCST) due to an appropriate ratio between hydrophilic and hydrophobic groups. The effects of reaction conditions on polymerization were investigated in detail. The structure of HPNPAM was characterized by (1)H NMR, FT-IR, Muti detector-size exclusion chromatography (MDSEC) and Ultravioletvisble (UV-Vis). The α value reached 0.20 and DB was 90%, indicating HPNPAMs with compact topology structure were successfully prepared. LCSTs were tuned by M(w) and the pH value of the solution. The change of molecular size was assayed by dynamic light scattering and scanning electron microscope. These results indicated that the stable uniform nanomicelles were destroyed and macromolecules aggregated together, forming large particles as temperature exceeded LCST. In addition, after the cells were incubated for 24 h, the cell viability reached 80%, which confirmed this new dual responsive HPNPAM had low cytotoxicity. MDPI 2016-04-08 /pmc/articles/PMC6432253/ /pubmed/30979223 http://dx.doi.org/10.3390/polym8040135 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zhou, Shijiao Zhang, Dongxin Bai, Libin Zhao, Jing Wu, Yonggang Zhao, Hongchi Ba, Xinwu The Synthesis of Backbone Thermo and pH Responsive Hyperbranched Poly(Bis(N,N-Propyl Acryl Amide))s by RAFT |
title | The Synthesis of Backbone Thermo and pH Responsive Hyperbranched Poly(Bis(N,N-Propyl Acryl Amide))s by RAFT |
title_full | The Synthesis of Backbone Thermo and pH Responsive Hyperbranched Poly(Bis(N,N-Propyl Acryl Amide))s by RAFT |
title_fullStr | The Synthesis of Backbone Thermo and pH Responsive Hyperbranched Poly(Bis(N,N-Propyl Acryl Amide))s by RAFT |
title_full_unstemmed | The Synthesis of Backbone Thermo and pH Responsive Hyperbranched Poly(Bis(N,N-Propyl Acryl Amide))s by RAFT |
title_short | The Synthesis of Backbone Thermo and pH Responsive Hyperbranched Poly(Bis(N,N-Propyl Acryl Amide))s by RAFT |
title_sort | synthesis of backbone thermo and ph responsive hyperbranched poly(bis(n,n-propyl acryl amide))s by raft |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432253/ https://www.ncbi.nlm.nih.gov/pubmed/30979223 http://dx.doi.org/10.3390/polym8040135 |
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