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A Gelated Colloidal Crystal Attached Lens for Noninvasive Continuous Monitoring of Tear Glucose
Patients of diabetes mellitus urgently need noninvasive and continuous glucose monitoring in daily point-of-care. As the tear glucose concentration has a positive correlation with that in blood, the hydrogel colloidal crystal integrated into contact lens possesses promising potential for noninvasive...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432312/ https://www.ncbi.nlm.nih.gov/pubmed/30970805 http://dx.doi.org/10.3390/polym9040125 |
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author | Ruan, Jia-Li Chen, Cheng Shen, Jian-Hua Zhao, Xue-Ling Qian, Shao-Hong Zhu, Zhi-Gang |
author_facet | Ruan, Jia-Li Chen, Cheng Shen, Jian-Hua Zhao, Xue-Ling Qian, Shao-Hong Zhu, Zhi-Gang |
author_sort | Ruan, Jia-Li |
collection | PubMed |
description | Patients of diabetes mellitus urgently need noninvasive and continuous glucose monitoring in daily point-of-care. As the tear glucose concentration has a positive correlation with that in blood, the hydrogel colloidal crystal integrated into contact lens possesses promising potential for noninvasive monitoring of glucose in tears. This paper presents a new glucose-responsive sensor, which consists a crystalline colloidal array (CCA) embedded in hydrogel matrix, attached onto a rigid gas permeable (RGP) contact lens. This novel sensing lens is able to selectively diffract visible light, whose wavelength shifts between 567 and 468 nm according to the alternation of the glucose concentration between 0 and 50 mM and its visible color change between reddish yellow, green, and blue. The detection limit of responsive glucose concentration can be reduced to 0.05 mM. Its combination with a contact lens endows it with excellent biocompatibility and portability, which shows great possibility for it to push the development of glucose-detecting devices into new era. |
format | Online Article Text |
id | pubmed-6432312 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64323122019-04-02 A Gelated Colloidal Crystal Attached Lens for Noninvasive Continuous Monitoring of Tear Glucose Ruan, Jia-Li Chen, Cheng Shen, Jian-Hua Zhao, Xue-Ling Qian, Shao-Hong Zhu, Zhi-Gang Polymers (Basel) Article Patients of diabetes mellitus urgently need noninvasive and continuous glucose monitoring in daily point-of-care. As the tear glucose concentration has a positive correlation with that in blood, the hydrogel colloidal crystal integrated into contact lens possesses promising potential for noninvasive monitoring of glucose in tears. This paper presents a new glucose-responsive sensor, which consists a crystalline colloidal array (CCA) embedded in hydrogel matrix, attached onto a rigid gas permeable (RGP) contact lens. This novel sensing lens is able to selectively diffract visible light, whose wavelength shifts between 567 and 468 nm according to the alternation of the glucose concentration between 0 and 50 mM and its visible color change between reddish yellow, green, and blue. The detection limit of responsive glucose concentration can be reduced to 0.05 mM. Its combination with a contact lens endows it with excellent biocompatibility and portability, which shows great possibility for it to push the development of glucose-detecting devices into new era. MDPI 2017-03-28 /pmc/articles/PMC6432312/ /pubmed/30970805 http://dx.doi.org/10.3390/polym9040125 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ruan, Jia-Li Chen, Cheng Shen, Jian-Hua Zhao, Xue-Ling Qian, Shao-Hong Zhu, Zhi-Gang A Gelated Colloidal Crystal Attached Lens for Noninvasive Continuous Monitoring of Tear Glucose |
title | A Gelated Colloidal Crystal Attached Lens for Noninvasive Continuous Monitoring of Tear Glucose |
title_full | A Gelated Colloidal Crystal Attached Lens for Noninvasive Continuous Monitoring of Tear Glucose |
title_fullStr | A Gelated Colloidal Crystal Attached Lens for Noninvasive Continuous Monitoring of Tear Glucose |
title_full_unstemmed | A Gelated Colloidal Crystal Attached Lens for Noninvasive Continuous Monitoring of Tear Glucose |
title_short | A Gelated Colloidal Crystal Attached Lens for Noninvasive Continuous Monitoring of Tear Glucose |
title_sort | gelated colloidal crystal attached lens for noninvasive continuous monitoring of tear glucose |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432312/ https://www.ncbi.nlm.nih.gov/pubmed/30970805 http://dx.doi.org/10.3390/polym9040125 |
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