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Synthetic biology approaches for improving photosynthesis
The phenomenal increase in agricultural yields that we have witnessed in the last century has slowed down as we approach the limits of selective breeding and optimization of cultivation techniques. To support the yield increase required to feed an ever-growing population, we will have to identify ne...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432428/ https://www.ncbi.nlm.nih.gov/pubmed/30715460 http://dx.doi.org/10.1093/jxb/erz029 |
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author | Kubis, Armin Bar-Even, Arren |
author_facet | Kubis, Armin Bar-Even, Arren |
author_sort | Kubis, Armin |
collection | PubMed |
description | The phenomenal increase in agricultural yields that we have witnessed in the last century has slowed down as we approach the limits of selective breeding and optimization of cultivation techniques. To support the yield increase required to feed an ever-growing population, we will have to identify new ways to boost the efficiency with which plants convert light into biomass. This challenge could potentially be tackled using state-of-the-art synthetic biology techniques to rewrite plant carbon fixation. In this review, we use recent studies to discuss and demonstrate different approaches for enhancing carbon fixation, including engineering Rubisco for higher activity, specificity, and activation; changing the expression level of enzymes within the Calvin cycle to avoid kinetic bottlenecks; introducing carbon-concentrating mechanisms such as inorganic carbon transporters, carboxysomes, and C(4) metabolism; and rewiring photorespiration towards more energetically efficient routes or pathways that do not release CO(2). We conclude by noting the importance of prioritizing and combining different approaches towards continuous and sustainable increase of plant productivities. |
format | Online Article Text |
id | pubmed-6432428 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-64324282019-04-01 Synthetic biology approaches for improving photosynthesis Kubis, Armin Bar-Even, Arren J Exp Bot Expert Views The phenomenal increase in agricultural yields that we have witnessed in the last century has slowed down as we approach the limits of selective breeding and optimization of cultivation techniques. To support the yield increase required to feed an ever-growing population, we will have to identify new ways to boost the efficiency with which plants convert light into biomass. This challenge could potentially be tackled using state-of-the-art synthetic biology techniques to rewrite plant carbon fixation. In this review, we use recent studies to discuss and demonstrate different approaches for enhancing carbon fixation, including engineering Rubisco for higher activity, specificity, and activation; changing the expression level of enzymes within the Calvin cycle to avoid kinetic bottlenecks; introducing carbon-concentrating mechanisms such as inorganic carbon transporters, carboxysomes, and C(4) metabolism; and rewiring photorespiration towards more energetically efficient routes or pathways that do not release CO(2). We conclude by noting the importance of prioritizing and combining different approaches towards continuous and sustainable increase of plant productivities. Oxford University Press 2019-02-15 2019-01-31 /pmc/articles/PMC6432428/ /pubmed/30715460 http://dx.doi.org/10.1093/jxb/erz029 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Experimental Biology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Expert Views Kubis, Armin Bar-Even, Arren Synthetic biology approaches for improving photosynthesis |
title | Synthetic biology approaches for improving photosynthesis |
title_full | Synthetic biology approaches for improving photosynthesis |
title_fullStr | Synthetic biology approaches for improving photosynthesis |
title_full_unstemmed | Synthetic biology approaches for improving photosynthesis |
title_short | Synthetic biology approaches for improving photosynthesis |
title_sort | synthetic biology approaches for improving photosynthesis |
topic | Expert Views |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432428/ https://www.ncbi.nlm.nih.gov/pubmed/30715460 http://dx.doi.org/10.1093/jxb/erz029 |
work_keys_str_mv | AT kubisarmin syntheticbiologyapproachesforimprovingphotosynthesis AT barevenarren syntheticbiologyapproachesforimprovingphotosynthesis |