Toxicity, Biocompatibility, pH-Responsiveness and Methotrexate Release from PVA/Hyaluronic Acid Cryogels for Psoriasis Therapy

Poly(vinyl alcohol)/hyaluronic acid cryogels loaded with methotrexate were studied. The physical–chemical characterization of cryogels was performed by FT-IR spectroscopy, scanning electron microscopy, differential scanning calorimetry and dynamic mechanical thermal analysis. Acute toxicity and haem...

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Autores principales: Cheaburu Yilmaz, Cătălina Natalia, Pamfil, Daniela, Vasile, Cornelia, Bibire, Nela, Lupuşoru, Raoul-Vasile, Zamfir, Carmen-Lăcrămioara, Lupușoru, Cătălina Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432429/
https://www.ncbi.nlm.nih.gov/pubmed/30970803
http://dx.doi.org/10.3390/polym9040123
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author Cheaburu Yilmaz, Cătălina Natalia
Pamfil, Daniela
Vasile, Cornelia
Bibire, Nela
Lupuşoru, Raoul-Vasile
Zamfir, Carmen-Lăcrămioara
Lupușoru, Cătălina Elena
author_facet Cheaburu Yilmaz, Cătălina Natalia
Pamfil, Daniela
Vasile, Cornelia
Bibire, Nela
Lupuşoru, Raoul-Vasile
Zamfir, Carmen-Lăcrămioara
Lupușoru, Cătălina Elena
author_sort Cheaburu Yilmaz, Cătălina Natalia
collection PubMed
description Poly(vinyl alcohol)/hyaluronic acid cryogels loaded with methotrexate were studied. The physical–chemical characterization of cryogels was performed by FT-IR spectroscopy, scanning electron microscopy, differential scanning calorimetry and dynamic mechanical thermal analysis. Acute toxicity and haematological parameters were determined by “in vivo” tests. The biocompatibility tests proved that the obtained cryogels showed significantly decreased toxicity and are biocompatible. The pH-responsiveness of the swelling behaviour and of the methotrexate release from the poly(vinyl alcohol)/hyaluronic acid (PVA/HA) cryogels were studied in a pH interval of 2–7.4. A significant change in properties was found at pH 5.5 specific for treatment of affected skin in psoriasis disease.
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spelling pubmed-64324292019-04-02 Toxicity, Biocompatibility, pH-Responsiveness and Methotrexate Release from PVA/Hyaluronic Acid Cryogels for Psoriasis Therapy Cheaburu Yilmaz, Cătălina Natalia Pamfil, Daniela Vasile, Cornelia Bibire, Nela Lupuşoru, Raoul-Vasile Zamfir, Carmen-Lăcrămioara Lupușoru, Cătălina Elena Polymers (Basel) Article Poly(vinyl alcohol)/hyaluronic acid cryogels loaded with methotrexate were studied. The physical–chemical characterization of cryogels was performed by FT-IR spectroscopy, scanning electron microscopy, differential scanning calorimetry and dynamic mechanical thermal analysis. Acute toxicity and haematological parameters were determined by “in vivo” tests. The biocompatibility tests proved that the obtained cryogels showed significantly decreased toxicity and are biocompatible. The pH-responsiveness of the swelling behaviour and of the methotrexate release from the poly(vinyl alcohol)/hyaluronic acid (PVA/HA) cryogels were studied in a pH interval of 2–7.4. A significant change in properties was found at pH 5.5 specific for treatment of affected skin in psoriasis disease. MDPI 2017-03-27 /pmc/articles/PMC6432429/ /pubmed/30970803 http://dx.doi.org/10.3390/polym9040123 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cheaburu Yilmaz, Cătălina Natalia
Pamfil, Daniela
Vasile, Cornelia
Bibire, Nela
Lupuşoru, Raoul-Vasile
Zamfir, Carmen-Lăcrămioara
Lupușoru, Cătălina Elena
Toxicity, Biocompatibility, pH-Responsiveness and Methotrexate Release from PVA/Hyaluronic Acid Cryogels for Psoriasis Therapy
title Toxicity, Biocompatibility, pH-Responsiveness and Methotrexate Release from PVA/Hyaluronic Acid Cryogels for Psoriasis Therapy
title_full Toxicity, Biocompatibility, pH-Responsiveness and Methotrexate Release from PVA/Hyaluronic Acid Cryogels for Psoriasis Therapy
title_fullStr Toxicity, Biocompatibility, pH-Responsiveness and Methotrexate Release from PVA/Hyaluronic Acid Cryogels for Psoriasis Therapy
title_full_unstemmed Toxicity, Biocompatibility, pH-Responsiveness and Methotrexate Release from PVA/Hyaluronic Acid Cryogels for Psoriasis Therapy
title_short Toxicity, Biocompatibility, pH-Responsiveness and Methotrexate Release from PVA/Hyaluronic Acid Cryogels for Psoriasis Therapy
title_sort toxicity, biocompatibility, ph-responsiveness and methotrexate release from pva/hyaluronic acid cryogels for psoriasis therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432429/
https://www.ncbi.nlm.nih.gov/pubmed/30970803
http://dx.doi.org/10.3390/polym9040123
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