Polyester-Based, Biodegradable Core-Multishell Nanocarriers for the Transport of Hydrophobic Drugs

A water-soluble, core-multishell (CMS) nanocarrier based on a new hyperbranched polyester core building block was synthesized and characterized towards drug transport and degradation of the nanocarrier. The hydrophobic drug dexamethasone was encapsulated and the enzyme-mediated biodegradability was...

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Detalles Bibliográficos
Autores principales: Walker, Karolina A., Stumbé, Jean-François, Haag, Rainer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432435/
https://www.ncbi.nlm.nih.gov/pubmed/30979288
http://dx.doi.org/10.3390/polym8050192
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author Walker, Karolina A.
Stumbé, Jean-François
Haag, Rainer
author_facet Walker, Karolina A.
Stumbé, Jean-François
Haag, Rainer
author_sort Walker, Karolina A.
collection PubMed
description A water-soluble, core-multishell (CMS) nanocarrier based on a new hyperbranched polyester core building block was synthesized and characterized towards drug transport and degradation of the nanocarrier. The hydrophobic drug dexamethasone was encapsulated and the enzyme-mediated biodegradability was investigated by NMR spectroscopy. The new CMS nanocarrier can transport one molecule of dexamethasone and degrades within five days at a skin temperature of 32 °C to biocompatible fragments.
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spelling pubmed-64324352019-04-02 Polyester-Based, Biodegradable Core-Multishell Nanocarriers for the Transport of Hydrophobic Drugs Walker, Karolina A. Stumbé, Jean-François Haag, Rainer Polymers (Basel) Article A water-soluble, core-multishell (CMS) nanocarrier based on a new hyperbranched polyester core building block was synthesized and characterized towards drug transport and degradation of the nanocarrier. The hydrophobic drug dexamethasone was encapsulated and the enzyme-mediated biodegradability was investigated by NMR spectroscopy. The new CMS nanocarrier can transport one molecule of dexamethasone and degrades within five days at a skin temperature of 32 °C to biocompatible fragments. MDPI 2016-05-14 /pmc/articles/PMC6432435/ /pubmed/30979288 http://dx.doi.org/10.3390/polym8050192 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Walker, Karolina A.
Stumbé, Jean-François
Haag, Rainer
Polyester-Based, Biodegradable Core-Multishell Nanocarriers for the Transport of Hydrophobic Drugs
title Polyester-Based, Biodegradable Core-Multishell Nanocarriers for the Transport of Hydrophobic Drugs
title_full Polyester-Based, Biodegradable Core-Multishell Nanocarriers for the Transport of Hydrophobic Drugs
title_fullStr Polyester-Based, Biodegradable Core-Multishell Nanocarriers for the Transport of Hydrophobic Drugs
title_full_unstemmed Polyester-Based, Biodegradable Core-Multishell Nanocarriers for the Transport of Hydrophobic Drugs
title_short Polyester-Based, Biodegradable Core-Multishell Nanocarriers for the Transport of Hydrophobic Drugs
title_sort polyester-based, biodegradable core-multishell nanocarriers for the transport of hydrophobic drugs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432435/
https://www.ncbi.nlm.nih.gov/pubmed/30979288
http://dx.doi.org/10.3390/polym8050192
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AT stumbejeanfrancois polyesterbasedbiodegradablecoremultishellnanocarriersforthetransportofhydrophobicdrugs
AT haagrainer polyesterbasedbiodegradablecoremultishellnanocarriersforthetransportofhydrophobicdrugs

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