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Stimuli-Responsive Block Copolymer-Based Assemblies for Cargo Delivery and Theranostic Applications
Although a number of tactics towards the fabrication and biomedical exploration of stimuli-responsive polymeric assemblies being responsive and adaptive to various factors have appeared, the controlled preparation of assemblies with well-defined physicochemical properties and tailor-made functions a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432437/ https://www.ncbi.nlm.nih.gov/pubmed/30974545 http://dx.doi.org/10.3390/polym8070268 |
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author | Yin, Jun Chen, Yu Zhang, Zhi-Huang Han, Xin |
author_facet | Yin, Jun Chen, Yu Zhang, Zhi-Huang Han, Xin |
author_sort | Yin, Jun |
collection | PubMed |
description | Although a number of tactics towards the fabrication and biomedical exploration of stimuli-responsive polymeric assemblies being responsive and adaptive to various factors have appeared, the controlled preparation of assemblies with well-defined physicochemical properties and tailor-made functions are still challenges. These responsive polymeric assemblies, which are triggered by stimuli, always exhibited reversible or irreversible changes in chemical structures and physical properties. However, simple drug/polymer nanocomplexes cannot deliver or release drugs into the diseased sites and cells on-demand due to the inevitable biological barriers. Hence, utilizing therapeutic or imaging agents-loaded stimuli-responsive block copolymer assemblies that are responsive to tumor internal microenvironments (pH, redox, enzyme, and temperature, etc.) or external stimuli (light and electromagnetic field, etc.) have emerged to be an important solution to improve therapeutic efficacy and imaging sensitivity through rationally designing as well as self-assembling approaches. In this review, we summarize a portion of recent progress in tumor and intracellular microenvironment responsive block copolymer assemblies and their applications in anticancer drug delivery and triggered release and enhanced imaging sensitivity. The outlook on future developments is also discussed. We hope that this review can stimulate more revolutionary ideas and novel concepts and meet the significant interest to diverse readers. |
format | Online Article Text |
id | pubmed-6432437 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64324372019-04-02 Stimuli-Responsive Block Copolymer-Based Assemblies for Cargo Delivery and Theranostic Applications Yin, Jun Chen, Yu Zhang, Zhi-Huang Han, Xin Polymers (Basel) Review Although a number of tactics towards the fabrication and biomedical exploration of stimuli-responsive polymeric assemblies being responsive and adaptive to various factors have appeared, the controlled preparation of assemblies with well-defined physicochemical properties and tailor-made functions are still challenges. These responsive polymeric assemblies, which are triggered by stimuli, always exhibited reversible or irreversible changes in chemical structures and physical properties. However, simple drug/polymer nanocomplexes cannot deliver or release drugs into the diseased sites and cells on-demand due to the inevitable biological barriers. Hence, utilizing therapeutic or imaging agents-loaded stimuli-responsive block copolymer assemblies that are responsive to tumor internal microenvironments (pH, redox, enzyme, and temperature, etc.) or external stimuli (light and electromagnetic field, etc.) have emerged to be an important solution to improve therapeutic efficacy and imaging sensitivity through rationally designing as well as self-assembling approaches. In this review, we summarize a portion of recent progress in tumor and intracellular microenvironment responsive block copolymer assemblies and their applications in anticancer drug delivery and triggered release and enhanced imaging sensitivity. The outlook on future developments is also discussed. We hope that this review can stimulate more revolutionary ideas and novel concepts and meet the significant interest to diverse readers. MDPI 2016-07-22 /pmc/articles/PMC6432437/ /pubmed/30974545 http://dx.doi.org/10.3390/polym8070268 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Yin, Jun Chen, Yu Zhang, Zhi-Huang Han, Xin Stimuli-Responsive Block Copolymer-Based Assemblies for Cargo Delivery and Theranostic Applications |
title | Stimuli-Responsive Block Copolymer-Based Assemblies for Cargo Delivery and Theranostic Applications |
title_full | Stimuli-Responsive Block Copolymer-Based Assemblies for Cargo Delivery and Theranostic Applications |
title_fullStr | Stimuli-Responsive Block Copolymer-Based Assemblies for Cargo Delivery and Theranostic Applications |
title_full_unstemmed | Stimuli-Responsive Block Copolymer-Based Assemblies for Cargo Delivery and Theranostic Applications |
title_short | Stimuli-Responsive Block Copolymer-Based Assemblies for Cargo Delivery and Theranostic Applications |
title_sort | stimuli-responsive block copolymer-based assemblies for cargo delivery and theranostic applications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432437/ https://www.ncbi.nlm.nih.gov/pubmed/30974545 http://dx.doi.org/10.3390/polym8070268 |
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