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Application of Collagen Scaffold in Tissue Engineering: Recent Advances and New Perspectives
Collagen is the main structural protein of most hard and soft tissues in animals and the human body, which plays an important role in maintaining the biological and structural integrity of the extracellular matrix (ECM) and provides physical support to tissues. Collagen can be extracted and purified...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432532/ https://www.ncbi.nlm.nih.gov/pubmed/30979136 http://dx.doi.org/10.3390/polym8020042 |
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author | Dong, Chanjuan Lv, Yonggang |
author_facet | Dong, Chanjuan Lv, Yonggang |
author_sort | Dong, Chanjuan |
collection | PubMed |
description | Collagen is the main structural protein of most hard and soft tissues in animals and the human body, which plays an important role in maintaining the biological and structural integrity of the extracellular matrix (ECM) and provides physical support to tissues. Collagen can be extracted and purified from a variety of sources and offers low immunogenicity, a porous structure, good permeability, biocompatibility and biodegradability. Collagen scaffolds have been widely used in tissue engineering due to these excellent properties. However, the poor mechanical property of collagen scaffolds limits their applications to some extent. To overcome this shortcoming, collagen scaffolds can be cross-linked by chemical or physical methods or modified with natural/synthetic polymers or inorganic materials. Biochemical factors can also be introduced to the scaffold to further improve its biological activity. This review will summarize the structure and biological characteristics of collagen and introduce the preparation methods and modification strategies of collagen scaffolds. The typical application of a collagen scaffold in tissue engineering (including nerve, bone, cartilage, tendon, ligament, blood vessel and skin) will be further provided. The prospects and challenges about their future research and application will also be pointed out. |
format | Online Article Text |
id | pubmed-6432532 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64325322019-04-02 Application of Collagen Scaffold in Tissue Engineering: Recent Advances and New Perspectives Dong, Chanjuan Lv, Yonggang Polymers (Basel) Review Collagen is the main structural protein of most hard and soft tissues in animals and the human body, which plays an important role in maintaining the biological and structural integrity of the extracellular matrix (ECM) and provides physical support to tissues. Collagen can be extracted and purified from a variety of sources and offers low immunogenicity, a porous structure, good permeability, biocompatibility and biodegradability. Collagen scaffolds have been widely used in tissue engineering due to these excellent properties. However, the poor mechanical property of collagen scaffolds limits their applications to some extent. To overcome this shortcoming, collagen scaffolds can be cross-linked by chemical or physical methods or modified with natural/synthetic polymers or inorganic materials. Biochemical factors can also be introduced to the scaffold to further improve its biological activity. This review will summarize the structure and biological characteristics of collagen and introduce the preparation methods and modification strategies of collagen scaffolds. The typical application of a collagen scaffold in tissue engineering (including nerve, bone, cartilage, tendon, ligament, blood vessel and skin) will be further provided. The prospects and challenges about their future research and application will also be pointed out. MDPI 2016-02-04 /pmc/articles/PMC6432532/ /pubmed/30979136 http://dx.doi.org/10.3390/polym8020042 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Dong, Chanjuan Lv, Yonggang Application of Collagen Scaffold in Tissue Engineering: Recent Advances and New Perspectives |
title | Application of Collagen Scaffold in Tissue Engineering: Recent Advances and New Perspectives |
title_full | Application of Collagen Scaffold in Tissue Engineering: Recent Advances and New Perspectives |
title_fullStr | Application of Collagen Scaffold in Tissue Engineering: Recent Advances and New Perspectives |
title_full_unstemmed | Application of Collagen Scaffold in Tissue Engineering: Recent Advances and New Perspectives |
title_short | Application of Collagen Scaffold in Tissue Engineering: Recent Advances and New Perspectives |
title_sort | application of collagen scaffold in tissue engineering: recent advances and new perspectives |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432532/ https://www.ncbi.nlm.nih.gov/pubmed/30979136 http://dx.doi.org/10.3390/polym8020042 |
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