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Seaweed Polysaccharide-Based Nanoparticles: Preparation and Applications for Drug Delivery

In recent years, there have been major advances and increasing amounts of research on the utilization of natural polymeric materials as drug delivery vehicles due to their biocompatibility and biodegradability. Seaweed polysaccharides are abundant resources and have been extensively studied for seve...

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Autores principales: Venkatesan, Jayachandran, Anil, Sukumaran, Kim, Se-Kwon, Shim, Min Suk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432598/
https://www.ncbi.nlm.nih.gov/pubmed/30979124
http://dx.doi.org/10.3390/polym8020030
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author Venkatesan, Jayachandran
Anil, Sukumaran
Kim, Se-Kwon
Shim, Min Suk
author_facet Venkatesan, Jayachandran
Anil, Sukumaran
Kim, Se-Kwon
Shim, Min Suk
author_sort Venkatesan, Jayachandran
collection PubMed
description In recent years, there have been major advances and increasing amounts of research on the utilization of natural polymeric materials as drug delivery vehicles due to their biocompatibility and biodegradability. Seaweed polysaccharides are abundant resources and have been extensively studied for several biological, biomedical, and functional food applications. The exploration of seaweed polysaccharides for drug delivery applications is still in its infancy. Alginate, carrageenan, fucoidan, ulvan, and laminarin are polysaccharides commonly isolated from seaweed. These natural polymers can be converted into nanoparticles (NPs) by different types of methods, such as ionic gelation, emulsion, and polyelectrolyte complexing. Ionic gelation and polyelectrolyte complexing are commonly employed by adding cationic molecules to these anionic polymers to produce NPs of a desired shape, size, and charge. In the present review, we have discussed the preparation of seaweed polysaccharide-based NPs using different types of methods as well as their usage as carriers for the delivery of various therapeutic molecules (e.g., proteins, peptides, anti-cancer drugs, and antibiotics). Seaweed polysaccharide-based NPs exhibit suitable particle size, high drug encapsulation, and sustained drug release with high biocompatibility, thereby demonstrating their high potential for safe and efficient drug delivery.
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spelling pubmed-64325982019-04-02 Seaweed Polysaccharide-Based Nanoparticles: Preparation and Applications for Drug Delivery Venkatesan, Jayachandran Anil, Sukumaran Kim, Se-Kwon Shim, Min Suk Polymers (Basel) Review In recent years, there have been major advances and increasing amounts of research on the utilization of natural polymeric materials as drug delivery vehicles due to their biocompatibility and biodegradability. Seaweed polysaccharides are abundant resources and have been extensively studied for several biological, biomedical, and functional food applications. The exploration of seaweed polysaccharides for drug delivery applications is still in its infancy. Alginate, carrageenan, fucoidan, ulvan, and laminarin are polysaccharides commonly isolated from seaweed. These natural polymers can be converted into nanoparticles (NPs) by different types of methods, such as ionic gelation, emulsion, and polyelectrolyte complexing. Ionic gelation and polyelectrolyte complexing are commonly employed by adding cationic molecules to these anionic polymers to produce NPs of a desired shape, size, and charge. In the present review, we have discussed the preparation of seaweed polysaccharide-based NPs using different types of methods as well as their usage as carriers for the delivery of various therapeutic molecules (e.g., proteins, peptides, anti-cancer drugs, and antibiotics). Seaweed polysaccharide-based NPs exhibit suitable particle size, high drug encapsulation, and sustained drug release with high biocompatibility, thereby demonstrating their high potential for safe and efficient drug delivery. MDPI 2016-01-26 /pmc/articles/PMC6432598/ /pubmed/30979124 http://dx.doi.org/10.3390/polym8020030 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Venkatesan, Jayachandran
Anil, Sukumaran
Kim, Se-Kwon
Shim, Min Suk
Seaweed Polysaccharide-Based Nanoparticles: Preparation and Applications for Drug Delivery
title Seaweed Polysaccharide-Based Nanoparticles: Preparation and Applications for Drug Delivery
title_full Seaweed Polysaccharide-Based Nanoparticles: Preparation and Applications for Drug Delivery
title_fullStr Seaweed Polysaccharide-Based Nanoparticles: Preparation and Applications for Drug Delivery
title_full_unstemmed Seaweed Polysaccharide-Based Nanoparticles: Preparation and Applications for Drug Delivery
title_short Seaweed Polysaccharide-Based Nanoparticles: Preparation and Applications for Drug Delivery
title_sort seaweed polysaccharide-based nanoparticles: preparation and applications for drug delivery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432598/
https://www.ncbi.nlm.nih.gov/pubmed/30979124
http://dx.doi.org/10.3390/polym8020030
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