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Potential Impact of Phellinus linteus on Adherence to Adjuvant Treatment After Curative Resection of Pancreatic Ductal Adenocarcinoma: Outcomes of a Propensity Score–Matched Analysis

Background: Surgical resection followed by adjuvant chemotherapy is the only therapeutic option in pancreatic cancer. However, there is limited research evaluating methods of improving adherence to adjuvant treatment after curative resection. Methods: From January 1995 to December 2014, 323 patients...

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Autores principales: Lee, Sung Hwan, Hwang, Ho Kyoung, Kang, Chang Moo, Lee, Woo Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432682/
https://www.ncbi.nlm.nih.gov/pubmed/30501431
http://dx.doi.org/10.1177/1534735418816825
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author Lee, Sung Hwan
Hwang, Ho Kyoung
Kang, Chang Moo
Lee, Woo Jung
author_facet Lee, Sung Hwan
Hwang, Ho Kyoung
Kang, Chang Moo
Lee, Woo Jung
author_sort Lee, Sung Hwan
collection PubMed
description Background: Surgical resection followed by adjuvant chemotherapy is the only therapeutic option in pancreatic cancer. However, there is limited research evaluating methods of improving adherence to adjuvant treatment after curative resection. Methods: From January 1995 to December 2014, 323 patients with pancreatic cancer who underwent pancreatectomy at the Severance Hospital were enrolled in this study. We retrospectively analyzed clinicopathologic factors with propensity score matching method. Results: The final study population was 217, after excluding patients undergoing neoadjuvant treatment or palliative resection, those who died within 30 days after operation, and those lost to follow-up after discharge. Among them, 161 received adjuvant treatment after curative resection. Cox’s proportional hazard models revealed that nodal metastasis, perioperative transfusion, and completion of adjuvant treatment were significantly correlated with cancer recurrence and cancer-related death (P < .05). Phellinus linteus (PL) medication was the only significant predictor for completion of adjuvant treatment after curative resection in logistic regression analysis (P = .039). Disease-free and overall survival of the PL medication group were significantly higher than the no PL medication group (P < .05). Conclusions: PL medication potentially contributed to long-term oncologic outcomes by increasing patients’ adherence to postoperative adjuvant chemotherapy, which resulted from PL medication associated with low toxicity of chemotherapy.
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spelling pubmed-64326822019-03-28 Potential Impact of Phellinus linteus on Adherence to Adjuvant Treatment After Curative Resection of Pancreatic Ductal Adenocarcinoma: Outcomes of a Propensity Score–Matched Analysis Lee, Sung Hwan Hwang, Ho Kyoung Kang, Chang Moo Lee, Woo Jung Integr Cancer Ther Research Article Background: Surgical resection followed by adjuvant chemotherapy is the only therapeutic option in pancreatic cancer. However, there is limited research evaluating methods of improving adherence to adjuvant treatment after curative resection. Methods: From January 1995 to December 2014, 323 patients with pancreatic cancer who underwent pancreatectomy at the Severance Hospital were enrolled in this study. We retrospectively analyzed clinicopathologic factors with propensity score matching method. Results: The final study population was 217, after excluding patients undergoing neoadjuvant treatment or palliative resection, those who died within 30 days after operation, and those lost to follow-up after discharge. Among them, 161 received adjuvant treatment after curative resection. Cox’s proportional hazard models revealed that nodal metastasis, perioperative transfusion, and completion of adjuvant treatment were significantly correlated with cancer recurrence and cancer-related death (P < .05). Phellinus linteus (PL) medication was the only significant predictor for completion of adjuvant treatment after curative resection in logistic regression analysis (P = .039). Disease-free and overall survival of the PL medication group were significantly higher than the no PL medication group (P < .05). Conclusions: PL medication potentially contributed to long-term oncologic outcomes by increasing patients’ adherence to postoperative adjuvant chemotherapy, which resulted from PL medication associated with low toxicity of chemotherapy. SAGE Publications 2018-12-03 /pmc/articles/PMC6432682/ /pubmed/30501431 http://dx.doi.org/10.1177/1534735418816825 Text en © The Author(s) 2019 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Research Article
Lee, Sung Hwan
Hwang, Ho Kyoung
Kang, Chang Moo
Lee, Woo Jung
Potential Impact of Phellinus linteus on Adherence to Adjuvant Treatment After Curative Resection of Pancreatic Ductal Adenocarcinoma: Outcomes of a Propensity Score–Matched Analysis
title Potential Impact of Phellinus linteus on Adherence to Adjuvant Treatment After Curative Resection of Pancreatic Ductal Adenocarcinoma: Outcomes of a Propensity Score–Matched Analysis
title_full Potential Impact of Phellinus linteus on Adherence to Adjuvant Treatment After Curative Resection of Pancreatic Ductal Adenocarcinoma: Outcomes of a Propensity Score–Matched Analysis
title_fullStr Potential Impact of Phellinus linteus on Adherence to Adjuvant Treatment After Curative Resection of Pancreatic Ductal Adenocarcinoma: Outcomes of a Propensity Score–Matched Analysis
title_full_unstemmed Potential Impact of Phellinus linteus on Adherence to Adjuvant Treatment After Curative Resection of Pancreatic Ductal Adenocarcinoma: Outcomes of a Propensity Score–Matched Analysis
title_short Potential Impact of Phellinus linteus on Adherence to Adjuvant Treatment After Curative Resection of Pancreatic Ductal Adenocarcinoma: Outcomes of a Propensity Score–Matched Analysis
title_sort potential impact of phellinus linteus on adherence to adjuvant treatment after curative resection of pancreatic ductal adenocarcinoma: outcomes of a propensity score–matched analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432682/
https://www.ncbi.nlm.nih.gov/pubmed/30501431
http://dx.doi.org/10.1177/1534735418816825
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