Synthetic lethality of cytolytic HSV-1 in cancer cells with ATRX and PML deficiency

Cancers that utilize the alternative lengthening of telomeres (ALT) mechanism for telomere maintenance are often difficult to treat and have a poor prognosis. They are also commonly deficient for expression of ATRX protein, a repressor of ALT activity, and a component of promyelocytic leukemia nucle...

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Detalles Bibliográficos
Autores principales: Han, Mingqi, Napier, Christine E., Frölich, Sonja, Teber, Erdahl, Wong, Ted, Noble, Jane R., Choi, Eugene H. Y., Everett, Roger D., Cesare, Anthony J., Reddel, Roger R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432714/
https://www.ncbi.nlm.nih.gov/pubmed/30745338
http://dx.doi.org/10.1242/jcs.222349

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