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Therapeutic Plasma Exchange as Management of Complicated Systemic Lupus Erythematosus and Other Autoimmune Diseases

INTRODUCTION: Autoimmune diseases include a diverse and complex group of pathologies with a broad clinical spectrum due to the production of autoantibodies, which generates multisystemic compromise. Therapeutic plasma exchange (TPE) is a good additive treatment for immunosuppression due to its actio...

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Autores principales: Aguirre-Valencia, David, Naranjo-Escobar, Juan, Posso-Osorio, Iván, Macía-Mejía, María Carmenza, Nieto-Aristizábal, Ivana, Barrera, Tatiana, Obando, María Alejandra, Tobón, Gabriel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432729/
https://www.ncbi.nlm.nih.gov/pubmed/30984421
http://dx.doi.org/10.1155/2019/5350960
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author Aguirre-Valencia, David
Naranjo-Escobar, Juan
Posso-Osorio, Iván
Macía-Mejía, María Carmenza
Nieto-Aristizábal, Ivana
Barrera, Tatiana
Obando, María Alejandra
Tobón, Gabriel J.
author_facet Aguirre-Valencia, David
Naranjo-Escobar, Juan
Posso-Osorio, Iván
Macía-Mejía, María Carmenza
Nieto-Aristizábal, Ivana
Barrera, Tatiana
Obando, María Alejandra
Tobón, Gabriel J.
author_sort Aguirre-Valencia, David
collection PubMed
description INTRODUCTION: Autoimmune diseases include a diverse and complex group of pathologies with a broad clinical spectrum due to the production of autoantibodies, which generates multisystemic compromise. Therapeutic plasma exchange (TPE) is a good additive treatment for immunosuppression due to its action over the autoantibodies. OBJECTIVES: To describe the main clinical characteristics and outcomes of patients with systemic lupus erythematosus and other systemic autoimmune diseases managed with TPE. METHODOLOGY: This descriptive retrospective study enrolled patients with systemic autoimmune diseases who received TPE. RESULTS: In total, 66 patients with a median age of 33.5 years (24-53 years) were included; the majority were females [n=51 (77.27%)]. Forty (60.61%) patients were diagnosed with systemic lupus erythematosus. In these cases, the main indication for TPE was diffuse alveolar hemorrhage (DAH; n=20, 30.3%) and neurolupus (n=9, 13.6%). No TPE-related deaths occurred, and the main complication was hemorrhage, without significant differences among the four types of TPE solutions used. The overall outcome was improvement in 41 (62.12%) patients. CONCLUSION: TPE is safe and effective in patients with severe manifestations of autoimmune diseases.
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spelling pubmed-64327292019-04-14 Therapeutic Plasma Exchange as Management of Complicated Systemic Lupus Erythematosus and Other Autoimmune Diseases Aguirre-Valencia, David Naranjo-Escobar, Juan Posso-Osorio, Iván Macía-Mejía, María Carmenza Nieto-Aristizábal, Ivana Barrera, Tatiana Obando, María Alejandra Tobón, Gabriel J. Autoimmune Dis Research Article INTRODUCTION: Autoimmune diseases include a diverse and complex group of pathologies with a broad clinical spectrum due to the production of autoantibodies, which generates multisystemic compromise. Therapeutic plasma exchange (TPE) is a good additive treatment for immunosuppression due to its action over the autoantibodies. OBJECTIVES: To describe the main clinical characteristics and outcomes of patients with systemic lupus erythematosus and other systemic autoimmune diseases managed with TPE. METHODOLOGY: This descriptive retrospective study enrolled patients with systemic autoimmune diseases who received TPE. RESULTS: In total, 66 patients with a median age of 33.5 years (24-53 years) were included; the majority were females [n=51 (77.27%)]. Forty (60.61%) patients were diagnosed with systemic lupus erythematosus. In these cases, the main indication for TPE was diffuse alveolar hemorrhage (DAH; n=20, 30.3%) and neurolupus (n=9, 13.6%). No TPE-related deaths occurred, and the main complication was hemorrhage, without significant differences among the four types of TPE solutions used. The overall outcome was improvement in 41 (62.12%) patients. CONCLUSION: TPE is safe and effective in patients with severe manifestations of autoimmune diseases. Hindawi 2019-03-11 /pmc/articles/PMC6432729/ /pubmed/30984421 http://dx.doi.org/10.1155/2019/5350960 Text en Copyright © 2019 David Aguirre-Valencia et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Aguirre-Valencia, David
Naranjo-Escobar, Juan
Posso-Osorio, Iván
Macía-Mejía, María Carmenza
Nieto-Aristizábal, Ivana
Barrera, Tatiana
Obando, María Alejandra
Tobón, Gabriel J.
Therapeutic Plasma Exchange as Management of Complicated Systemic Lupus Erythematosus and Other Autoimmune Diseases
title Therapeutic Plasma Exchange as Management of Complicated Systemic Lupus Erythematosus and Other Autoimmune Diseases
title_full Therapeutic Plasma Exchange as Management of Complicated Systemic Lupus Erythematosus and Other Autoimmune Diseases
title_fullStr Therapeutic Plasma Exchange as Management of Complicated Systemic Lupus Erythematosus and Other Autoimmune Diseases
title_full_unstemmed Therapeutic Plasma Exchange as Management of Complicated Systemic Lupus Erythematosus and Other Autoimmune Diseases
title_short Therapeutic Plasma Exchange as Management of Complicated Systemic Lupus Erythematosus and Other Autoimmune Diseases
title_sort therapeutic plasma exchange as management of complicated systemic lupus erythematosus and other autoimmune diseases
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432729/
https://www.ncbi.nlm.nih.gov/pubmed/30984421
http://dx.doi.org/10.1155/2019/5350960
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