The combination of a neprilysin inhibitor (sacubitril) and angiotensin-II receptor blocker (valsartan) attenuates glomerular and tubular injury in the Zucker Obese rat

OBJECTIVE: Diabetic nephropathy (DN) is characterized by glomerular and tubulointerstitial injury, proteinuria and remodeling. Here we examined whether the combination of an inhibitor of neprilysin (sacubitril), a natriuretic peptide-degrading enzyme, and an angiotensin II type 1 receptor blocker (v...

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Detalles Bibliográficos
Autores principales: Habibi, Javad, Aroor, Annayya R., Das, Nitin A., Manrique-Acevedo, Camila M., Johnson, Megan S., Hayden, Melvin R., Nistala, Ravi, Wiedmeyer, Charles, Chandrasekar, Bysani, DeMarco, Vincent G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432760/
https://www.ncbi.nlm.nih.gov/pubmed/30909895
http://dx.doi.org/10.1186/s12933-019-0847-8

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