Combination of Clindamycin and Azithromycin as Alternative Treatment for Toxoplasma gondii Encephalitis

Current standard therapies for toxoplasmic encephalitis often cause severe adverse events. A 57-year-old HIV-positive man in Japan who had toxoplasmic encephalitis but was intolerant to trimethoprim/sulfamethoxazole, pyrimethamine, sulfadiazine, and atovaquone was successfully treated with the combi...

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Detalles Bibliográficos
Autores principales: Shiojiri, Daisuke, Kinai, Ei, Teruya, Katsuji, Kikuchi, Yoshimi, Oka, Shinichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2019
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433045/
https://www.ncbi.nlm.nih.gov/pubmed/30882331
http://dx.doi.org/10.3201/eid2504.181689
Descripción
Sumario:Current standard therapies for toxoplasmic encephalitis often cause severe adverse events. A 57-year-old HIV-positive man in Japan who had toxoplasmic encephalitis but was intolerant to trimethoprim/sulfamethoxazole, pyrimethamine, sulfadiazine, and atovaquone was successfully treated with the combination of clindamycin and azithromycin. This drug combination can be an alternative treatment for this condition.

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