Combination of Clindamycin and Azithromycin as Alternative Treatment for Toxoplasma gondii Encephalitis

Current standard therapies for toxoplasmic encephalitis often cause severe adverse events. A 57-year-old HIV-positive man in Japan who had toxoplasmic encephalitis but was intolerant to trimethoprim/sulfamethoxazole, pyrimethamine, sulfadiazine, and atovaquone was successfully treated with the combi...

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Autores principales: Shiojiri, Daisuke, Kinai, Ei, Teruya, Katsuji, Kikuchi, Yoshimi, Oka, Shinichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2019
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433045/
https://www.ncbi.nlm.nih.gov/pubmed/30882331
http://dx.doi.org/10.3201/eid2504.181689
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author Shiojiri, Daisuke
Kinai, Ei
Teruya, Katsuji
Kikuchi, Yoshimi
Oka, Shinichi
author_facet Shiojiri, Daisuke
Kinai, Ei
Teruya, Katsuji
Kikuchi, Yoshimi
Oka, Shinichi
author_sort Shiojiri, Daisuke
collection PubMed
description Current standard therapies for toxoplasmic encephalitis often cause severe adverse events. A 57-year-old HIV-positive man in Japan who had toxoplasmic encephalitis but was intolerant to trimethoprim/sulfamethoxazole, pyrimethamine, sulfadiazine, and atovaquone was successfully treated with the combination of clindamycin and azithromycin. This drug combination can be an alternative treatment for this condition.
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spelling pubmed-64330452019-04-03 Combination of Clindamycin and Azithromycin as Alternative Treatment for Toxoplasma gondii Encephalitis Shiojiri, Daisuke Kinai, Ei Teruya, Katsuji Kikuchi, Yoshimi Oka, Shinichi Emerg Infect Dis Research Letter Current standard therapies for toxoplasmic encephalitis often cause severe adverse events. A 57-year-old HIV-positive man in Japan who had toxoplasmic encephalitis but was intolerant to trimethoprim/sulfamethoxazole, pyrimethamine, sulfadiazine, and atovaquone was successfully treated with the combination of clindamycin and azithromycin. This drug combination can be an alternative treatment for this condition. Centers for Disease Control and Prevention 2019-04 /pmc/articles/PMC6433045/ /pubmed/30882331 http://dx.doi.org/10.3201/eid2504.181689 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research Letter
Shiojiri, Daisuke
Kinai, Ei
Teruya, Katsuji
Kikuchi, Yoshimi
Oka, Shinichi
Combination of Clindamycin and Azithromycin as Alternative Treatment for Toxoplasma gondii Encephalitis
title Combination of Clindamycin and Azithromycin as Alternative Treatment for Toxoplasma gondii Encephalitis
title_full Combination of Clindamycin and Azithromycin as Alternative Treatment for Toxoplasma gondii Encephalitis
title_fullStr Combination of Clindamycin and Azithromycin as Alternative Treatment for Toxoplasma gondii Encephalitis
title_full_unstemmed Combination of Clindamycin and Azithromycin as Alternative Treatment for Toxoplasma gondii Encephalitis
title_short Combination of Clindamycin and Azithromycin as Alternative Treatment for Toxoplasma gondii Encephalitis
title_sort combination of clindamycin and azithromycin as alternative treatment for toxoplasma gondii encephalitis
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433045/
https://www.ncbi.nlm.nih.gov/pubmed/30882331
http://dx.doi.org/10.3201/eid2504.181689
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