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Cigarette Smoking Preferentially Affects Intracranial Vessels in Young Males: A Propensity-Score Matching Analysis
PURPOSE: Cigarette smoking (CS) is one of the major risk factors of cerebral atherosclerotic disease, however, its level of contribution to extracranial and intracranial atherosclerotic stenosis (ECAS and ICAS) was not fully revealed yet. The purpose of our study was to assess the association of CS...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society of Interventional Neuroradiology
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433193/ https://www.ncbi.nlm.nih.gov/pubmed/30827064 http://dx.doi.org/10.5469/neuroint.2018.01123 |
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author | Song, Yunsun Lee, Dongwhane Suh, Dae Chul Kim, Joong-goo Kim, Jae Kyun Han, Minkyu Liu, Hairi Zhao, Lingbo Kim, Eun Hye Jung, Sung Chul Lee, Dong-geun Koo, Hyun Jung Kim, Min-ju Baek, Seunghee Hwang, Seon Moon Kim, Bum Joon Kim, Yeon-Jung Cho, Hong-Jun Kim, Sang Joon Jeon, Sang-Beom Kim, Jong S. |
author_facet | Song, Yunsun Lee, Dongwhane Suh, Dae Chul Kim, Joong-goo Kim, Jae Kyun Han, Minkyu Liu, Hairi Zhao, Lingbo Kim, Eun Hye Jung, Sung Chul Lee, Dong-geun Koo, Hyun Jung Kim, Min-ju Baek, Seunghee Hwang, Seon Moon Kim, Bum Joon Kim, Yeon-Jung Cho, Hong-Jun Kim, Sang Joon Jeon, Sang-Beom Kim, Jong S. |
author_sort | Song, Yunsun |
collection | PubMed |
description | PURPOSE: Cigarette smoking (CS) is one of the major risk factors of cerebral atherosclerotic disease, however, its level of contribution to extracranial and intracranial atherosclerotic stenosis (ECAS and ICAS) was not fully revealed yet. The purpose of our study was to assess the association of CS to cerebral atherosclerosis along with other risk factors. MATERIALS AND METHODS: All consecutive patients who were angiographically confirmed with severe symptomatic cerebral atherosclerotic disease between January 2002 and December 2012 were included in this study. Multivariate logistic regression analyses were performed to identify risk factors for ECAS and ICAS. Thereafter, CS group were compared to non-CS group in the entire study population and in a propensity-score matched population with two different age-subgroups. RESULTS: Of 1709 enrolled patients, 794 (46.5%) had extracranial (EC) lesions and the other 915 (53.5%) had intracranial (IC) lesions. CS group had more EC lesions (55.8% vs. 35.3%, P<0.001) whereas young age group (<50 years) had more IC lesion (84.5% vs. 47.6%, P<0.001). In multivariate analysis, seven variables including CS, male, old age, coronary heart disease, higher erythrocyte sedimentation rate, multiple lesions, and anterior lesion were independently associated with ECAS. In the propensity-score matched CS group had significant more EC lesion compared to non-CS group (65.7% vs. 47.9%) only in the old age subgroup. CONCLUSION: In contrast to a significant association between CS and severe symptomatic ECAS shown in old population, young patients did not show this association and showed relatively higher preference of ICAS. |
format | Online Article Text |
id | pubmed-6433193 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Korean Society of Interventional Neuroradiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-64331932019-04-02 Cigarette Smoking Preferentially Affects Intracranial Vessels in Young Males: A Propensity-Score Matching Analysis Song, Yunsun Lee, Dongwhane Suh, Dae Chul Kim, Joong-goo Kim, Jae Kyun Han, Minkyu Liu, Hairi Zhao, Lingbo Kim, Eun Hye Jung, Sung Chul Lee, Dong-geun Koo, Hyun Jung Kim, Min-ju Baek, Seunghee Hwang, Seon Moon Kim, Bum Joon Kim, Yeon-Jung Cho, Hong-Jun Kim, Sang Joon Jeon, Sang-Beom Kim, Jong S. Neurointervention Original Paper PURPOSE: Cigarette smoking (CS) is one of the major risk factors of cerebral atherosclerotic disease, however, its level of contribution to extracranial and intracranial atherosclerotic stenosis (ECAS and ICAS) was not fully revealed yet. The purpose of our study was to assess the association of CS to cerebral atherosclerosis along with other risk factors. MATERIALS AND METHODS: All consecutive patients who were angiographically confirmed with severe symptomatic cerebral atherosclerotic disease between January 2002 and December 2012 were included in this study. Multivariate logistic regression analyses were performed to identify risk factors for ECAS and ICAS. Thereafter, CS group were compared to non-CS group in the entire study population and in a propensity-score matched population with two different age-subgroups. RESULTS: Of 1709 enrolled patients, 794 (46.5%) had extracranial (EC) lesions and the other 915 (53.5%) had intracranial (IC) lesions. CS group had more EC lesions (55.8% vs. 35.3%, P<0.001) whereas young age group (<50 years) had more IC lesion (84.5% vs. 47.6%, P<0.001). In multivariate analysis, seven variables including CS, male, old age, coronary heart disease, higher erythrocyte sedimentation rate, multiple lesions, and anterior lesion were independently associated with ECAS. In the propensity-score matched CS group had significant more EC lesion compared to non-CS group (65.7% vs. 47.9%) only in the old age subgroup. CONCLUSION: In contrast to a significant association between CS and severe symptomatic ECAS shown in old population, young patients did not show this association and showed relatively higher preference of ICAS. Korean Society of Interventional Neuroradiology 2019-03 2019-02-28 /pmc/articles/PMC6433193/ /pubmed/30827064 http://dx.doi.org/10.5469/neuroint.2018.01123 Text en Copyright © 2019 Korean Society of Interventional Neuroradiology This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Paper Song, Yunsun Lee, Dongwhane Suh, Dae Chul Kim, Joong-goo Kim, Jae Kyun Han, Minkyu Liu, Hairi Zhao, Lingbo Kim, Eun Hye Jung, Sung Chul Lee, Dong-geun Koo, Hyun Jung Kim, Min-ju Baek, Seunghee Hwang, Seon Moon Kim, Bum Joon Kim, Yeon-Jung Cho, Hong-Jun Kim, Sang Joon Jeon, Sang-Beom Kim, Jong S. Cigarette Smoking Preferentially Affects Intracranial Vessels in Young Males: A Propensity-Score Matching Analysis |
title | Cigarette Smoking Preferentially Affects Intracranial Vessels in Young Males: A Propensity-Score Matching Analysis |
title_full | Cigarette Smoking Preferentially Affects Intracranial Vessels in Young Males: A Propensity-Score Matching Analysis |
title_fullStr | Cigarette Smoking Preferentially Affects Intracranial Vessels in Young Males: A Propensity-Score Matching Analysis |
title_full_unstemmed | Cigarette Smoking Preferentially Affects Intracranial Vessels in Young Males: A Propensity-Score Matching Analysis |
title_short | Cigarette Smoking Preferentially Affects Intracranial Vessels in Young Males: A Propensity-Score Matching Analysis |
title_sort | cigarette smoking preferentially affects intracranial vessels in young males: a propensity-score matching analysis |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433193/ https://www.ncbi.nlm.nih.gov/pubmed/30827064 http://dx.doi.org/10.5469/neuroint.2018.01123 |
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