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Treadmill Exercise Alleviates Circadian Rhythm Disruption-Induced Memory Deficits by Activation of Glucocorticoid Receptor and Brain-Derived Neurotrophic Factor-Dependent Pathway

PURPOSE: Circadian rhythm affects learning process, memory consolidation, and long-term memory. In this study, the alleviating effect of exercise on circadian rhythm disruption-induced memory deficits was investigated. METHODS: BMAL1 knockdown transgenic mice (BMAL1 TG) were used as the BMAL1-TG gro...

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Autores principales: Kim, Sung-Eun, Ko, Il-Gyu, Ji, Eun-Sang, Jin, Jun-Jang, Hwang, Lakkyong, Kim, Sang-Hoon, Cho, Sehyung, Kim, Chang-Ju, Kim, Kyungjin, Kim, Khae Hawn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Continence Society 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433206/
https://www.ncbi.nlm.nih.gov/pubmed/30832466
http://dx.doi.org/10.5213/inj.1938048.024
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author Kim, Sung-Eun
Ko, Il-Gyu
Ji, Eun-Sang
Jin, Jun-Jang
Hwang, Lakkyong
Kim, Sang-Hoon
Cho, Sehyung
Kim, Chang-Ju
Kim, Kyungjin
Kim, Khae Hawn
author_facet Kim, Sung-Eun
Ko, Il-Gyu
Ji, Eun-Sang
Jin, Jun-Jang
Hwang, Lakkyong
Kim, Sang-Hoon
Cho, Sehyung
Kim, Chang-Ju
Kim, Kyungjin
Kim, Khae Hawn
author_sort Kim, Sung-Eun
collection PubMed
description PURPOSE: Circadian rhythm affects learning process, memory consolidation, and long-term memory. In this study, the alleviating effect of exercise on circadian rhythm disruption-induced memory deficits was investigated. METHODS: BMAL1 knockdown transgenic mice (BMAL1 TG) were used as the BMAL1-TG group and the BMAL1-TG with treadmill exercise group. Female C57BL/6J mice of the same age were used as the wildtype group and the wildtype with treadmill exercise group. The mice in the treadmill exercise groups performed running on a motorized treadmill under the dark-dark conditions for 8 weeks. Short-term memory, nonspatial object memory, and spatial learning memory were determined using stepdown avoidance test, novel object-recognition test, and radial 8-arm maze test. Immunohistochemistry for doublecortin and 5-bromo-2’-deoxyuridine was conducted for the determination of hippocampal neurogenesis. Using the western blot analysis, we determined the expressions of glucocorticoid receptor (GR) and factors related to the neurogenesis and memory consolidation, such as brain-derived neurotrophic factor, tyrosine kinase B, p44/42 mitogen-activated protein kinase, cyclic AMP-responsive element binding protein, phosphatidylinositol 3-kinase, protein kinas B, protein kinase C alpha, early-growth-response gene 1. RESULTS: Circadian rhythm disruption impaired memory function through inhibiting the expressions of GR and the factors related to neurogenesis and memory consolidation. Treadmill exercise improved memory function via enhancing the expressions of GR and above-mentioned factors. CONCLUSIONS: Treadmill exercise acts as the zeitgeber that improves memory function under the circadian rhythm disrupted conditions.
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spelling pubmed-64332062019-03-28 Treadmill Exercise Alleviates Circadian Rhythm Disruption-Induced Memory Deficits by Activation of Glucocorticoid Receptor and Brain-Derived Neurotrophic Factor-Dependent Pathway Kim, Sung-Eun Ko, Il-Gyu Ji, Eun-Sang Jin, Jun-Jang Hwang, Lakkyong Kim, Sang-Hoon Cho, Sehyung Kim, Chang-Ju Kim, Kyungjin Kim, Khae Hawn Int Neurourol J Original Article PURPOSE: Circadian rhythm affects learning process, memory consolidation, and long-term memory. In this study, the alleviating effect of exercise on circadian rhythm disruption-induced memory deficits was investigated. METHODS: BMAL1 knockdown transgenic mice (BMAL1 TG) were used as the BMAL1-TG group and the BMAL1-TG with treadmill exercise group. Female C57BL/6J mice of the same age were used as the wildtype group and the wildtype with treadmill exercise group. The mice in the treadmill exercise groups performed running on a motorized treadmill under the dark-dark conditions for 8 weeks. Short-term memory, nonspatial object memory, and spatial learning memory were determined using stepdown avoidance test, novel object-recognition test, and radial 8-arm maze test. Immunohistochemistry for doublecortin and 5-bromo-2’-deoxyuridine was conducted for the determination of hippocampal neurogenesis. Using the western blot analysis, we determined the expressions of glucocorticoid receptor (GR) and factors related to the neurogenesis and memory consolidation, such as brain-derived neurotrophic factor, tyrosine kinase B, p44/42 mitogen-activated protein kinase, cyclic AMP-responsive element binding protein, phosphatidylinositol 3-kinase, protein kinas B, protein kinase C alpha, early-growth-response gene 1. RESULTS: Circadian rhythm disruption impaired memory function through inhibiting the expressions of GR and the factors related to neurogenesis and memory consolidation. Treadmill exercise improved memory function via enhancing the expressions of GR and above-mentioned factors. CONCLUSIONS: Treadmill exercise acts as the zeitgeber that improves memory function under the circadian rhythm disrupted conditions. Korean Continence Society 2019-02 2019-02-28 /pmc/articles/PMC6433206/ /pubmed/30832466 http://dx.doi.org/10.5213/inj.1938048.024 Text en Copyright © 2019 Korean Continence Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Sung-Eun
Ko, Il-Gyu
Ji, Eun-Sang
Jin, Jun-Jang
Hwang, Lakkyong
Kim, Sang-Hoon
Cho, Sehyung
Kim, Chang-Ju
Kim, Kyungjin
Kim, Khae Hawn
Treadmill Exercise Alleviates Circadian Rhythm Disruption-Induced Memory Deficits by Activation of Glucocorticoid Receptor and Brain-Derived Neurotrophic Factor-Dependent Pathway
title Treadmill Exercise Alleviates Circadian Rhythm Disruption-Induced Memory Deficits by Activation of Glucocorticoid Receptor and Brain-Derived Neurotrophic Factor-Dependent Pathway
title_full Treadmill Exercise Alleviates Circadian Rhythm Disruption-Induced Memory Deficits by Activation of Glucocorticoid Receptor and Brain-Derived Neurotrophic Factor-Dependent Pathway
title_fullStr Treadmill Exercise Alleviates Circadian Rhythm Disruption-Induced Memory Deficits by Activation of Glucocorticoid Receptor and Brain-Derived Neurotrophic Factor-Dependent Pathway
title_full_unstemmed Treadmill Exercise Alleviates Circadian Rhythm Disruption-Induced Memory Deficits by Activation of Glucocorticoid Receptor and Brain-Derived Neurotrophic Factor-Dependent Pathway
title_short Treadmill Exercise Alleviates Circadian Rhythm Disruption-Induced Memory Deficits by Activation of Glucocorticoid Receptor and Brain-Derived Neurotrophic Factor-Dependent Pathway
title_sort treadmill exercise alleviates circadian rhythm disruption-induced memory deficits by activation of glucocorticoid receptor and brain-derived neurotrophic factor-dependent pathway
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433206/
https://www.ncbi.nlm.nih.gov/pubmed/30832466
http://dx.doi.org/10.5213/inj.1938048.024
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