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Dengue seroprevalence among asymptomatic blood donors during an epidemic outbreak in Central-West Brazil
Dengue virus (DENV) transmission by blood transfusion is an important route of viral acquisition during outbreaks. The prevalence of DENV markers (viral RNA, NS1, anti-DENV IgM, and IgG) among blood donors in Central-West Brazil has never been evaluated. Our aim was to evaluate the full set of serol...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433220/ https://www.ncbi.nlm.nih.gov/pubmed/30908528 http://dx.doi.org/10.1371/journal.pone.0213793 |
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| author | Slavov, Svetoslav Nanev Cilião-Alves, Daiani Cristina Gonzaga, Filipe Almeida Carvalho Moura, Drielly Rodrigues de Moura, Ana Carolina Alves Melo de Noronha, Lorena Aparecida Gonçalves Cassemiro, Évelin Mota Pimentel, Bárbara Maciel Sidou Costa, Fabiano José Queiroz da Silva, Grasiela Araújo Ramos, Doralina do Amaral Rabello de Araújo, Wildo Navegantes Kashima, Simone Haddad, Rodrigo |
| author_facet | Slavov, Svetoslav Nanev Cilião-Alves, Daiani Cristina Gonzaga, Filipe Almeida Carvalho Moura, Drielly Rodrigues de Moura, Ana Carolina Alves Melo de Noronha, Lorena Aparecida Gonçalves Cassemiro, Évelin Mota Pimentel, Bárbara Maciel Sidou Costa, Fabiano José Queiroz da Silva, Grasiela Araújo Ramos, Doralina do Amaral Rabello de Araújo, Wildo Navegantes Kashima, Simone Haddad, Rodrigo |
| author_sort | Slavov, Svetoslav Nanev |
| collection | PubMed |
| description | Dengue virus (DENV) transmission by blood transfusion is an important route of viral acquisition during outbreaks. The prevalence of DENV markers (viral RNA, NS1, anti-DENV IgM, and IgG) among blood donors in Central-West Brazil has never been evaluated. Our aim was to evaluate the full set of serological and molecular markers for DENV among blood donors of the Federal District of Brazil during an extensive outbreak in 2016. We found an anti-DENV IgM prevalence of 6.74% (n = 32/475). Of 475, 20 samples (4.21%) were also anti-DENV IgG positive. All samples were non-reactive for NS1 and DENV RNA. Our results imply that a significant proportion of the tested donors had experienced asymptomatic infection. More studies are necessary to evaluate the real prevalence of DENV viremia in blood donors from the Federal District of Brazil and if specific measures are needed to routinely test the blood donors for DENV RNA during outbreaks. |
| format | Online Article Text |
| id | pubmed-6433220 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | Public Library of Science |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-64332202019-04-08 Dengue seroprevalence among asymptomatic blood donors during an epidemic outbreak in Central-West Brazil Slavov, Svetoslav Nanev Cilião-Alves, Daiani Cristina Gonzaga, Filipe Almeida Carvalho Moura, Drielly Rodrigues de Moura, Ana Carolina Alves Melo de Noronha, Lorena Aparecida Gonçalves Cassemiro, Évelin Mota Pimentel, Bárbara Maciel Sidou Costa, Fabiano José Queiroz da Silva, Grasiela Araújo Ramos, Doralina do Amaral Rabello de Araújo, Wildo Navegantes Kashima, Simone Haddad, Rodrigo PLoS One Research Article Dengue virus (DENV) transmission by blood transfusion is an important route of viral acquisition during outbreaks. The prevalence of DENV markers (viral RNA, NS1, anti-DENV IgM, and IgG) among blood donors in Central-West Brazil has never been evaluated. Our aim was to evaluate the full set of serological and molecular markers for DENV among blood donors of the Federal District of Brazil during an extensive outbreak in 2016. We found an anti-DENV IgM prevalence of 6.74% (n = 32/475). Of 475, 20 samples (4.21%) were also anti-DENV IgG positive. All samples were non-reactive for NS1 and DENV RNA. Our results imply that a significant proportion of the tested donors had experienced asymptomatic infection. More studies are necessary to evaluate the real prevalence of DENV viremia in blood donors from the Federal District of Brazil and if specific measures are needed to routinely test the blood donors for DENV RNA during outbreaks. Public Library of Science 2019-03-25 /pmc/articles/PMC6433220/ /pubmed/30908528 http://dx.doi.org/10.1371/journal.pone.0213793 Text en © 2019 Slavov et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| spellingShingle | Research Article Slavov, Svetoslav Nanev Cilião-Alves, Daiani Cristina Gonzaga, Filipe Almeida Carvalho Moura, Drielly Rodrigues de Moura, Ana Carolina Alves Melo de Noronha, Lorena Aparecida Gonçalves Cassemiro, Évelin Mota Pimentel, Bárbara Maciel Sidou Costa, Fabiano José Queiroz da Silva, Grasiela Araújo Ramos, Doralina do Amaral Rabello de Araújo, Wildo Navegantes Kashima, Simone Haddad, Rodrigo Dengue seroprevalence among asymptomatic blood donors during an epidemic outbreak in Central-West Brazil |
| title | Dengue seroprevalence among asymptomatic blood donors during an epidemic outbreak in Central-West Brazil |
| title_full | Dengue seroprevalence among asymptomatic blood donors during an epidemic outbreak in Central-West Brazil |
| title_fullStr | Dengue seroprevalence among asymptomatic blood donors during an epidemic outbreak in Central-West Brazil |
| title_full_unstemmed | Dengue seroprevalence among asymptomatic blood donors during an epidemic outbreak in Central-West Brazil |
| title_short | Dengue seroprevalence among asymptomatic blood donors during an epidemic outbreak in Central-West Brazil |
| title_sort | dengue seroprevalence among asymptomatic blood donors during an epidemic outbreak in central-west brazil |
| topic | Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433220/ https://www.ncbi.nlm.nih.gov/pubmed/30908528 http://dx.doi.org/10.1371/journal.pone.0213793 |
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