Biophysical mechanisms in the mammalian respiratory oscillator re-examined with a new data-driven computational model

An autorhythmic population of excitatory neurons in the brainstem pre-Bötzinger complex is a critical component of the mammalian respiratory oscillator. Two intrinsic neuronal biophysical mechanisms—a persistent sodium current ([Formula: see text]) and a calcium-activated non-selective cationic curr...

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Detalles Bibliográficos
Autores principales: Phillips, Ryan S, John, Tibin T, Koizumi, Hidehiko, Molkov, Yaroslav I, Smith, Jeffrey C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433470/
https://www.ncbi.nlm.nih.gov/pubmed/30907727
http://dx.doi.org/10.7554/eLife.41555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433470/
https://www.ncbi.nlm.nih.gov/pubmed/30907727
http://dx.doi.org/10.7554/eLife.41555

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