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Depression in sleep disturbance: A review on a bidirectional relationship, mechanisms and treatment

Sleep disturbance is the most prominent symptom in depressive patients and was formerly regarded as a main secondary manifestation of depression. However, many longitudinal studies have identified insomnia as an independent risk factor for the development of emerging or recurrent depression among yo...

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Detalles Bibliográficos
Autores principales: Fang, Hong, Tu, Sheng, Sheng, Jifang, Shao, Anwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433686/
https://www.ncbi.nlm.nih.gov/pubmed/30734486
http://dx.doi.org/10.1111/jcmm.14170
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author Fang, Hong
Tu, Sheng
Sheng, Jifang
Shao, Anwen
author_facet Fang, Hong
Tu, Sheng
Sheng, Jifang
Shao, Anwen
author_sort Fang, Hong
collection PubMed
description Sleep disturbance is the most prominent symptom in depressive patients and was formerly regarded as a main secondary manifestation of depression. However, many longitudinal studies have identified insomnia as an independent risk factor for the development of emerging or recurrent depression among young, middle‐aged and older adults. This bidirectional association between sleep disturbance and depression has created a new perspective that sleep problems are no longer an epiphenomenon of depression but a predictive prodromal symptom. In this review, we highlight the treatment of sleep disturbance before, during and after depression, which probably plays an important role in improving outcomes and preventing the recurrence of depression. In clinical practice, pharmacological therapies, including hypnotics and antidepressants, and non‐pharmacological therapies are typically applied. A better understanding of the pathophysiological mechanisms between sleep disturbance and depression can help psychiatrists better manage this comorbidity.
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spelling pubmed-64336862019-04-08 Depression in sleep disturbance: A review on a bidirectional relationship, mechanisms and treatment Fang, Hong Tu, Sheng Sheng, Jifang Shao, Anwen J Cell Mol Med Reviews Sleep disturbance is the most prominent symptom in depressive patients and was formerly regarded as a main secondary manifestation of depression. However, many longitudinal studies have identified insomnia as an independent risk factor for the development of emerging or recurrent depression among young, middle‐aged and older adults. This bidirectional association between sleep disturbance and depression has created a new perspective that sleep problems are no longer an epiphenomenon of depression but a predictive prodromal symptom. In this review, we highlight the treatment of sleep disturbance before, during and after depression, which probably plays an important role in improving outcomes and preventing the recurrence of depression. In clinical practice, pharmacological therapies, including hypnotics and antidepressants, and non‐pharmacological therapies are typically applied. A better understanding of the pathophysiological mechanisms between sleep disturbance and depression can help psychiatrists better manage this comorbidity. John Wiley and Sons Inc. 2019-02-07 2019-04 /pmc/articles/PMC6433686/ /pubmed/30734486 http://dx.doi.org/10.1111/jcmm.14170 Text en © 2019 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Fang, Hong
Tu, Sheng
Sheng, Jifang
Shao, Anwen
Depression in sleep disturbance: A review on a bidirectional relationship, mechanisms and treatment
title Depression in sleep disturbance: A review on a bidirectional relationship, mechanisms and treatment
title_full Depression in sleep disturbance: A review on a bidirectional relationship, mechanisms and treatment
title_fullStr Depression in sleep disturbance: A review on a bidirectional relationship, mechanisms and treatment
title_full_unstemmed Depression in sleep disturbance: A review on a bidirectional relationship, mechanisms and treatment
title_short Depression in sleep disturbance: A review on a bidirectional relationship, mechanisms and treatment
title_sort depression in sleep disturbance: a review on a bidirectional relationship, mechanisms and treatment
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433686/
https://www.ncbi.nlm.nih.gov/pubmed/30734486
http://dx.doi.org/10.1111/jcmm.14170
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