FSH Beyond Fertility

The traditional view of follicle-stimulating hormone (FSH) as a reproductive hormone is changing. It has been shown that FSH receptors (FSHRs) are expressed in various extra-gonadal tissues and mediate the biological effects of FSH at those sites. Molecular, animal, epidemiologic, and clinical data...

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Detalles Bibliográficos
Autores principales: Lizneva, Daria, Rahimova, Alina, Kim, Se-Min, Atabiekov, Ihor, Javaid, Seher, Alamoush, Bateel, Taneja, Charit, Khan, Ayesha, Sun, Li, Azziz, Ricardo, Yuen, Tony, Zaidi, Mone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433784/
https://www.ncbi.nlm.nih.gov/pubmed/30941099
http://dx.doi.org/10.3389/fendo.2019.00136
Descripción
Sumario:The traditional view of follicle-stimulating hormone (FSH) as a reproductive hormone is changing. It has been shown that FSH receptors (FSHRs) are expressed in various extra-gonadal tissues and mediate the biological effects of FSH at those sites. Molecular, animal, epidemiologic, and clinical data suggest that elevated serum FSH may play a significant role in the evolution of bone loss and obesity, as well as contributing to cardiovascular and cancer risk. This review summarizes recent data on FSH action beyond reproduction.

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