FSH Beyond Fertility

The traditional view of follicle-stimulating hormone (FSH) as a reproductive hormone is changing. It has been shown that FSH receptors (FSHRs) are expressed in various extra-gonadal tissues and mediate the biological effects of FSH at those sites. Molecular, animal, epidemiologic, and clinical data...

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Autores principales: Lizneva, Daria, Rahimova, Alina, Kim, Se-Min, Atabiekov, Ihor, Javaid, Seher, Alamoush, Bateel, Taneja, Charit, Khan, Ayesha, Sun, Li, Azziz, Ricardo, Yuen, Tony, Zaidi, Mone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433784/
https://www.ncbi.nlm.nih.gov/pubmed/30941099
http://dx.doi.org/10.3389/fendo.2019.00136
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author Lizneva, Daria
Rahimova, Alina
Kim, Se-Min
Atabiekov, Ihor
Javaid, Seher
Alamoush, Bateel
Taneja, Charit
Khan, Ayesha
Sun, Li
Azziz, Ricardo
Yuen, Tony
Zaidi, Mone
author_facet Lizneva, Daria
Rahimova, Alina
Kim, Se-Min
Atabiekov, Ihor
Javaid, Seher
Alamoush, Bateel
Taneja, Charit
Khan, Ayesha
Sun, Li
Azziz, Ricardo
Yuen, Tony
Zaidi, Mone
author_sort Lizneva, Daria
collection PubMed
description The traditional view of follicle-stimulating hormone (FSH) as a reproductive hormone is changing. It has been shown that FSH receptors (FSHRs) are expressed in various extra-gonadal tissues and mediate the biological effects of FSH at those sites. Molecular, animal, epidemiologic, and clinical data suggest that elevated serum FSH may play a significant role in the evolution of bone loss and obesity, as well as contributing to cardiovascular and cancer risk. This review summarizes recent data on FSH action beyond reproduction.
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spelling pubmed-64337842019-04-02 FSH Beyond Fertility Lizneva, Daria Rahimova, Alina Kim, Se-Min Atabiekov, Ihor Javaid, Seher Alamoush, Bateel Taneja, Charit Khan, Ayesha Sun, Li Azziz, Ricardo Yuen, Tony Zaidi, Mone Front Endocrinol (Lausanne) Endocrinology The traditional view of follicle-stimulating hormone (FSH) as a reproductive hormone is changing. It has been shown that FSH receptors (FSHRs) are expressed in various extra-gonadal tissues and mediate the biological effects of FSH at those sites. Molecular, animal, epidemiologic, and clinical data suggest that elevated serum FSH may play a significant role in the evolution of bone loss and obesity, as well as contributing to cardiovascular and cancer risk. This review summarizes recent data on FSH action beyond reproduction. Frontiers Media S.A. 2019-03-19 /pmc/articles/PMC6433784/ /pubmed/30941099 http://dx.doi.org/10.3389/fendo.2019.00136 Text en Copyright © 2019 Lizneva, Rahimova, Kim, Atabiekov, Javaid, Alamoush, Taneja, Khan, Sun, Azziz, Yuen and Zaidi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Lizneva, Daria
Rahimova, Alina
Kim, Se-Min
Atabiekov, Ihor
Javaid, Seher
Alamoush, Bateel
Taneja, Charit
Khan, Ayesha
Sun, Li
Azziz, Ricardo
Yuen, Tony
Zaidi, Mone
FSH Beyond Fertility
title FSH Beyond Fertility
title_full FSH Beyond Fertility
title_fullStr FSH Beyond Fertility
title_full_unstemmed FSH Beyond Fertility
title_short FSH Beyond Fertility
title_sort fsh beyond fertility
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433784/
https://www.ncbi.nlm.nih.gov/pubmed/30941099
http://dx.doi.org/10.3389/fendo.2019.00136
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