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Mitochondrial Dysfunction in Huntington’s Disease; Interplay Between HSF1, p53 and PGC-1α Transcription Factors

Huntington’s disease (HD) is a neurodegenerative disease caused by an expanded CAG repeat in the huntingtin (HTT) gene, causing the protein to misfold and aggregate. HD progression is characterized by motor impairment and cognitive decline associated with the preferential loss of striatal medium spi...

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Detalles Bibliográficos
Autores principales:	Intihar, Taylor A., Martinez, Elisa A., Gomez-Pastor, Rocio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433789/ https://www.ncbi.nlm.nih.gov/pubmed/30941017 http://dx.doi.org/10.3389/fncel.2019.00103

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