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Cortical degeneration in chronic traumatic encephalopathy and Alzheimer’s disease neuropathologic change

OBJECTIVES: An observational study to compare the laminar distributions in frontal and temporal cortex of the tau-immunoreactive pathologies in chronic traumatic encephalopathy (CTE) and Alzheimer’s disease neuropathologic change (ADNC). PATIENTS: Post-mortem material of (1) four cases of CTE withou...

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Autores principales: Armstrong, Richard A., McKee, Ann C., Stein, Thor D., Alvarez, Victor E., Cairns, Nigel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433808/
https://www.ncbi.nlm.nih.gov/pubmed/30564964
http://dx.doi.org/10.1007/s10072-018-3686-6
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author Armstrong, Richard A.
McKee, Ann C.
Stein, Thor D.
Alvarez, Victor E.
Cairns, Nigel J.
author_facet Armstrong, Richard A.
McKee, Ann C.
Stein, Thor D.
Alvarez, Victor E.
Cairns, Nigel J.
author_sort Armstrong, Richard A.
collection PubMed
description OBJECTIVES: An observational study to compare the laminar distributions in frontal and temporal cortex of the tau-immunoreactive pathologies in chronic traumatic encephalopathy (CTE) and Alzheimer’s disease neuropathologic change (ADNC). PATIENTS: Post-mortem material of (1) four cases of CTE without ADNC, (2) seven cases of CTE with ADNC (CTE/ADNC), and (3) seven cases of ADNC alone. RESULTS: In CTE and CTE/ADNC, neurofibrillary tangles (NFT), neuropil threads (NT), and dot-like grains (DLG) were distributed either in upper cortex or across all layers. Low densities of astrocytic tangles (AT) and abnormally enlarged neurons (EN) were not localized to any specific layer. Surviving neurons exhibited peaks of density in both upper and lower cortex, and vacuole density was greatest in superficial layers. In ADNC, neuritic plaques (NP) were more frequent, AT rare, NFT and NT were more widely distributed, NT affected lower layers more frequently, and surviving neurons were less frequently bimodal than in CTE and CTE/ADNC. CONCLUSION: Tau pathology in CTE and CTE/ADNC consistently affected the upper cortex but was more widely distributed in ADNC. The presence of CTE may encourage the development of ADNC pathology later in the course of the disease.
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spelling pubmed-64338082019-03-26 Cortical degeneration in chronic traumatic encephalopathy and Alzheimer’s disease neuropathologic change Armstrong, Richard A. McKee, Ann C. Stein, Thor D. Alvarez, Victor E. Cairns, Nigel J. Neurol Sci Original Article OBJECTIVES: An observational study to compare the laminar distributions in frontal and temporal cortex of the tau-immunoreactive pathologies in chronic traumatic encephalopathy (CTE) and Alzheimer’s disease neuropathologic change (ADNC). PATIENTS: Post-mortem material of (1) four cases of CTE without ADNC, (2) seven cases of CTE with ADNC (CTE/ADNC), and (3) seven cases of ADNC alone. RESULTS: In CTE and CTE/ADNC, neurofibrillary tangles (NFT), neuropil threads (NT), and dot-like grains (DLG) were distributed either in upper cortex or across all layers. Low densities of astrocytic tangles (AT) and abnormally enlarged neurons (EN) were not localized to any specific layer. Surviving neurons exhibited peaks of density in both upper and lower cortex, and vacuole density was greatest in superficial layers. In ADNC, neuritic plaques (NP) were more frequent, AT rare, NFT and NT were more widely distributed, NT affected lower layers more frequently, and surviving neurons were less frequently bimodal than in CTE and CTE/ADNC. CONCLUSION: Tau pathology in CTE and CTE/ADNC consistently affected the upper cortex but was more widely distributed in ADNC. The presence of CTE may encourage the development of ADNC pathology later in the course of the disease. Springer International Publishing 2018-12-18 2019 /pmc/articles/PMC6433808/ /pubmed/30564964 http://dx.doi.org/10.1007/s10072-018-3686-6 Text en © The Author(s) 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Armstrong, Richard A.
McKee, Ann C.
Stein, Thor D.
Alvarez, Victor E.
Cairns, Nigel J.
Cortical degeneration in chronic traumatic encephalopathy and Alzheimer’s disease neuropathologic change
title Cortical degeneration in chronic traumatic encephalopathy and Alzheimer’s disease neuropathologic change
title_full Cortical degeneration in chronic traumatic encephalopathy and Alzheimer’s disease neuropathologic change
title_fullStr Cortical degeneration in chronic traumatic encephalopathy and Alzheimer’s disease neuropathologic change
title_full_unstemmed Cortical degeneration in chronic traumatic encephalopathy and Alzheimer’s disease neuropathologic change
title_short Cortical degeneration in chronic traumatic encephalopathy and Alzheimer’s disease neuropathologic change
title_sort cortical degeneration in chronic traumatic encephalopathy and alzheimer’s disease neuropathologic change
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433808/
https://www.ncbi.nlm.nih.gov/pubmed/30564964
http://dx.doi.org/10.1007/s10072-018-3686-6
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