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Sodium Zirconium Cyclosilicate: A Review in Hyperkalaemia
Sodium zirconium cyclosilicate (Lokelma™) [hereafter referred to as SZC] is a non-absorbed, non-polymer zirconium silicate compound that preferentially exchanges hydrogen and sodium for potassium and ammonium ions in the gastrointestinal tract (GIT), thereby increasing faecal potassium excretion and...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer International Publishing
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433811/ https://www.ncbi.nlm.nih.gov/pubmed/30306338 http://dx.doi.org/10.1007/s40265-018-0991-6 |
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author | Hoy, Sheridan M. |
author_facet | Hoy, Sheridan M. |
author_sort | Hoy, Sheridan M. |
collection | PubMed |
description | Sodium zirconium cyclosilicate (Lokelma™) [hereafter referred to as SZC] is a non-absorbed, non-polymer zirconium silicate compound that preferentially exchanges hydrogen and sodium for potassium and ammonium ions in the gastrointestinal tract (GIT), thereby increasing faecal potassium excretion and lowering serum potassium levels. It is available as a powder for oral suspension (in water) and is approved in the EU and the USA for the treatment of hyperkalaemia in adults. In two multinational, phase III studies in adults with hyperkalaemia, SZC 10 g three times daily lowered serum potassium levels to within the normal range (3.5–5.0 mmol/L) during the first 48 h of treatment, and SZC 5 and 10 g once daily maintained normokalaemia over ≤ 28 days’ therapy. These beneficial effects were consistent across all patient subgroups (e.g. chronic kidney disease, diabetes, heart failure, concomitant use of RAAS inhibitor therapy), and appeared to be maintained over the longer term (≤ 12 months). SZC was generally well tolerated in adults with hyperkalaemia. Its tolerability profile was generally similar to that seen with placebo over ≤ 28 day, and its safety profile appeared to remain consistent over the longer term (≤ 12 months). Moreover, the incidence of hypokalemia was low. Current evidence indicates that SZC is a promising therapy for the management of hyperkalaemia in adults. |
format | Online Article Text |
id | pubmed-6433811 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-64338112019-04-12 Sodium Zirconium Cyclosilicate: A Review in Hyperkalaemia Hoy, Sheridan M. Drugs Adis Drug Evaluation Sodium zirconium cyclosilicate (Lokelma™) [hereafter referred to as SZC] is a non-absorbed, non-polymer zirconium silicate compound that preferentially exchanges hydrogen and sodium for potassium and ammonium ions in the gastrointestinal tract (GIT), thereby increasing faecal potassium excretion and lowering serum potassium levels. It is available as a powder for oral suspension (in water) and is approved in the EU and the USA for the treatment of hyperkalaemia in adults. In two multinational, phase III studies in adults with hyperkalaemia, SZC 10 g three times daily lowered serum potassium levels to within the normal range (3.5–5.0 mmol/L) during the first 48 h of treatment, and SZC 5 and 10 g once daily maintained normokalaemia over ≤ 28 days’ therapy. These beneficial effects were consistent across all patient subgroups (e.g. chronic kidney disease, diabetes, heart failure, concomitant use of RAAS inhibitor therapy), and appeared to be maintained over the longer term (≤ 12 months). SZC was generally well tolerated in adults with hyperkalaemia. Its tolerability profile was generally similar to that seen with placebo over ≤ 28 day, and its safety profile appeared to remain consistent over the longer term (≤ 12 months). Moreover, the incidence of hypokalemia was low. Current evidence indicates that SZC is a promising therapy for the management of hyperkalaemia in adults. Springer International Publishing 2018-10-10 2018 /pmc/articles/PMC6433811/ /pubmed/30306338 http://dx.doi.org/10.1007/s40265-018-0991-6 Text en © Springer Nature 2019, corrected publication 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, duplication, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made. |
spellingShingle | Adis Drug Evaluation Hoy, Sheridan M. Sodium Zirconium Cyclosilicate: A Review in Hyperkalaemia |
title | Sodium Zirconium Cyclosilicate: A Review in Hyperkalaemia |
title_full | Sodium Zirconium Cyclosilicate: A Review in Hyperkalaemia |
title_fullStr | Sodium Zirconium Cyclosilicate: A Review in Hyperkalaemia |
title_full_unstemmed | Sodium Zirconium Cyclosilicate: A Review in Hyperkalaemia |
title_short | Sodium Zirconium Cyclosilicate: A Review in Hyperkalaemia |
title_sort | sodium zirconium cyclosilicate: a review in hyperkalaemia |
topic | Adis Drug Evaluation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433811/ https://www.ncbi.nlm.nih.gov/pubmed/30306338 http://dx.doi.org/10.1007/s40265-018-0991-6 |
work_keys_str_mv | AT hoysheridanm sodiumzirconiumcyclosilicateareviewinhyperkalaemia |