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Aquaporin‐4 deficiency reduces TGF‐β1 in mouse midbrains and exacerbates pathology in experimental Parkinson's disease

Aquaporin‐4 (AQP4), the main water‐selective membrane transport protein in the brain, is localized to the astrocyte plasma membrane. Following the establishment of a 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐induced Parkinson's disease (PD) model, AQP4‐deficient (AQP4(−/−)) mice displ...

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Detalles Bibliográficos
Autores principales: Xue, Xue, Zhang, Weiwei, Zhu, Jifeng, Chen, Xiaojun, Zhou, Sha, Xu, Zhipeng, Hu, Gang, Su, Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433854/
https://www.ncbi.nlm.nih.gov/pubmed/30680924
http://dx.doi.org/10.1111/jcmm.14147

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