Inhibition of DYRK1A-EGFR axis by p53-MDM2 cascade mediates the induction of cellular senescence

Activation of p53 may induce apoptosis or cellular senescence in stressed cells. We here report that epidermal growth factor receptor (EGFR) is downregulated by p53 activation in a subset of cancer cell lines, and this EGFR downregulation mediates cellular senescence caused by p53 activation. EGFR c...

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Detalles Bibliográficos
Autores principales: Xu, Xiuhua, Liu, Qiao, Zhang, Chen, Ren, Shuai, Xu, Limei, Zhao, Zixiao, Dou, Hao, Li, Peishan, Zhang, Xiyu, Gong, Yaoqin, Shao, Changshun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433862/
https://www.ncbi.nlm.nih.gov/pubmed/30910997
http://dx.doi.org/10.1038/s41419-019-1521-5

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