The cochaperone CHIP marks Hsp70- and Hsp90-bound substrates for degradation through a very flexible mechanism

Some molecular chaperones are involved not only in assisting the folding of proteins but also, given appropriate conditions, in their degradation. This is the case for Hsp70 and Hsp90 which, in concert with the cochaperone CHIP, direct their bound substrate to degradation through ubiquitination. We...

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Detalles Bibliográficos
Autores principales: Quintana-Gallardo, Lucía, Martín-Benito, Jaime, Marcilla, Miguel, Espadas, Guadalupe, Sabidó, Eduard, Valpuesta, José María
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433865/
https://www.ncbi.nlm.nih.gov/pubmed/30911017
http://dx.doi.org/10.1038/s41598-019-41060-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433865/
https://www.ncbi.nlm.nih.gov/pubmed/30911017
http://dx.doi.org/10.1038/s41598-019-41060-0

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