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Volumetric Reductions of Subcortical Structures and Their Localizations in Alcohol-Dependent Patients

Changes in brain morphometry have been extensively reported in various studies examining the effects of chronic alcohol use in alcohol-dependent patients. Such studies were able to confirm the association between chronic alcohol use and volumetric reductions in subcortical structures using FSL (FMRI...

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Autores principales: Shim, Jae-Hyuk, Kim, Yong-Tae, Kim, Siekyeong, Baek, Hyeon-Man
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433880/
https://www.ncbi.nlm.nih.gov/pubmed/30941093
http://dx.doi.org/10.3389/fneur.2019.00247
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author Shim, Jae-Hyuk
Kim, Yong-Tae
Kim, Siekyeong
Baek, Hyeon-Man
author_facet Shim, Jae-Hyuk
Kim, Yong-Tae
Kim, Siekyeong
Baek, Hyeon-Man
author_sort Shim, Jae-Hyuk
collection PubMed
description Changes in brain morphometry have been extensively reported in various studies examining the effects of chronic alcohol use in alcohol-dependent patients. Such studies were able to confirm the association between chronic alcohol use and volumetric reductions in subcortical structures using FSL (FMRIB software library). However, each study that utilized FSL had different sets of subcortical structures that showed significant volumetric reduction. First, we aimed to investigate the reproducibility of using FSL to assess volumetric differences of subcortical structures between alcohol-dependent patients and control subjects. Second, we aimed to use Vertex analysis, a less utilized program, to visually inspect 3D meshes of subcortical structures and observe significant shape abnormalities that occurred in each subcortical structure. Vertex analysis results from the hippocampus and thalamus were overlaid on top of their respective subregional atlases to further pinpoint the subregional locations where shape abnormalities occurred. We analyzed the volumes of 14 subcortical structures (bilateral thalamus, caudate, putamen, globus pallidus, hippocampus, amygdala, nucleus accumbens) in 21 alcohol-dependent subjects and 21 healthy controls using images acquired with 3T MRI. The images were run through various programs found in FSL, such as SIENAX, FIRST, and Vertex analysis. We found that in alcohol-dependent patients, the bilateral thalamus (left: p < 0.01, right: p = 0.01), bilateral putamen (left: p = 0.02, right: p < 0.01), right globus pallidus (p < 0.01), bilateral hippocampus (left: p = 0.05, right: p = 0.03) and bilateral nucleus accumbens (left: p = 0.05, right: p = 0.03) were significantly reduced compared to the corresponding subcortical structures of healthy controls. With vertex analysis, we observed surface reductions of the following hippocampal subfields: Presubiculum, hippocampal tail, hippocampal molecular layer, hippocampal fissure, fimbria, and CA3. We reproduced the assessment made in previous studies that reductions in subcortical volume were negatively associated with alcohol dependence by using the FMRIB Software Library. In addition, we identified the subfields of the thalamus and hippocampus that showed volumetric reduction.
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spelling pubmed-64338802019-04-02 Volumetric Reductions of Subcortical Structures and Their Localizations in Alcohol-Dependent Patients Shim, Jae-Hyuk Kim, Yong-Tae Kim, Siekyeong Baek, Hyeon-Man Front Neurol Neurology Changes in brain morphometry have been extensively reported in various studies examining the effects of chronic alcohol use in alcohol-dependent patients. Such studies were able to confirm the association between chronic alcohol use and volumetric reductions in subcortical structures using FSL (FMRIB software library). However, each study that utilized FSL had different sets of subcortical structures that showed significant volumetric reduction. First, we aimed to investigate the reproducibility of using FSL to assess volumetric differences of subcortical structures between alcohol-dependent patients and control subjects. Second, we aimed to use Vertex analysis, a less utilized program, to visually inspect 3D meshes of subcortical structures and observe significant shape abnormalities that occurred in each subcortical structure. Vertex analysis results from the hippocampus and thalamus were overlaid on top of their respective subregional atlases to further pinpoint the subregional locations where shape abnormalities occurred. We analyzed the volumes of 14 subcortical structures (bilateral thalamus, caudate, putamen, globus pallidus, hippocampus, amygdala, nucleus accumbens) in 21 alcohol-dependent subjects and 21 healthy controls using images acquired with 3T MRI. The images were run through various programs found in FSL, such as SIENAX, FIRST, and Vertex analysis. We found that in alcohol-dependent patients, the bilateral thalamus (left: p < 0.01, right: p = 0.01), bilateral putamen (left: p = 0.02, right: p < 0.01), right globus pallidus (p < 0.01), bilateral hippocampus (left: p = 0.05, right: p = 0.03) and bilateral nucleus accumbens (left: p = 0.05, right: p = 0.03) were significantly reduced compared to the corresponding subcortical structures of healthy controls. With vertex analysis, we observed surface reductions of the following hippocampal subfields: Presubiculum, hippocampal tail, hippocampal molecular layer, hippocampal fissure, fimbria, and CA3. We reproduced the assessment made in previous studies that reductions in subcortical volume were negatively associated with alcohol dependence by using the FMRIB Software Library. In addition, we identified the subfields of the thalamus and hippocampus that showed volumetric reduction. Frontiers Media S.A. 2019-03-19 /pmc/articles/PMC6433880/ /pubmed/30941093 http://dx.doi.org/10.3389/fneur.2019.00247 Text en Copyright © 2019 Shim, Kim, Kim and Baek. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Shim, Jae-Hyuk
Kim, Yong-Tae
Kim, Siekyeong
Baek, Hyeon-Man
Volumetric Reductions of Subcortical Structures and Their Localizations in Alcohol-Dependent Patients
title Volumetric Reductions of Subcortical Structures and Their Localizations in Alcohol-Dependent Patients
title_full Volumetric Reductions of Subcortical Structures and Their Localizations in Alcohol-Dependent Patients
title_fullStr Volumetric Reductions of Subcortical Structures and Their Localizations in Alcohol-Dependent Patients
title_full_unstemmed Volumetric Reductions of Subcortical Structures and Their Localizations in Alcohol-Dependent Patients
title_short Volumetric Reductions of Subcortical Structures and Their Localizations in Alcohol-Dependent Patients
title_sort volumetric reductions of subcortical structures and their localizations in alcohol-dependent patients
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433880/
https://www.ncbi.nlm.nih.gov/pubmed/30941093
http://dx.doi.org/10.3389/fneur.2019.00247
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