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Enhancing folic acid metabolism suppresses defects associated with loss of Drosophila mitofusin
Mutations in the mitochondrial GTPase mitofusin 2 (MFN2) cause Charcot-Marie-Tooth disease type 2 (CMT2A), a form of peripheral neuropathy that compromises axonal function. Mitofusins promote mitochondrial fusion and regulate mitochondrial dynamics. They are also reported to be involved in forming c...
Autores principales: | Garrido-Maraver, Juan, Celardo, Ivana, Costa, Ana C., Lehmann, Susann, Loh, Samantha H. Y., Martins, L. Miguel |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433915/ https://www.ncbi.nlm.nih.gov/pubmed/30911005 http://dx.doi.org/10.1038/s41419-019-1496-2 |
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