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Phase 1 Study Evaluating the Association of the Cyclin-Dependent Kinase 4/6 Inhibitor Ribociclib and Cetuximab in Recurrent/Metastatic p16-Negative Squamous Cell Carcinoma of the Head and Neck
Background: The majority of human papillomavirus (HPV)-negative squamous cell carcinoma of the head and neck (SCCHN) present upregulation of the epidermal growth factor receptor (EGFR) and frequent alterations in the cyclin D1-cyclin dependent kinase (CDK) 4/6 (CDK 4/6)-retinoblastoma protein (pRb)...
Autores principales: | , , , , , , , , |
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格式: | Online Artículo Texto |
語言: | English |
出版: |
Frontiers Media S.A.
2019
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主題: | |
在線閱讀: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433958/ https://www.ncbi.nlm.nih.gov/pubmed/30941307 http://dx.doi.org/10.3389/fonc.2019.00155 |