Past, Present, and Future Strategies for Enhanced Assessment of Embryo's Genome and Reproductive Competence in Women of Advanced Reproductive Age

Recent advancements in genomic analysis allow testing of an increasing number of genetic features in human preimplantation embryos. Typical single gene mutation and whole chromosomes testing can now be integrated with assessment of mitochondrial DNA and polygenic conditions. Diagnostic expansion int...

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Autores principales: Poli, Maurizio, Girardi, Laura, Fabiani, Marco, Moretto, Martina, Romanelli, Valeria, Patassini, Cristina, Zuccarello, Daniela, Capalbo, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433971/
https://www.ncbi.nlm.nih.gov/pubmed/30941103
http://dx.doi.org/10.3389/fendo.2019.00154
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author Poli, Maurizio
Girardi, Laura
Fabiani, Marco
Moretto, Martina
Romanelli, Valeria
Patassini, Cristina
Zuccarello, Daniela
Capalbo, Antonio
author_facet Poli, Maurizio
Girardi, Laura
Fabiani, Marco
Moretto, Martina
Romanelli, Valeria
Patassini, Cristina
Zuccarello, Daniela
Capalbo, Antonio
author_sort Poli, Maurizio
collection PubMed
description Recent advancements in genomic analysis allow testing of an increasing number of genetic features in human preimplantation embryos. Typical single gene mutation and whole chromosomes testing can now be integrated with assessment of mitochondrial DNA and polygenic conditions. Diagnostic expansion into epigenetic and transcriptomic assessment in the near future are potential technological targets which may improve the prognostic outlook of patients of advanced reproductive age and overall in vitro fertilization (IVF) treatment outcomes. In this review, we discuss the technological progress of recent years and their future applications in preimplantation genetic testing in IVF.
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spelling pubmed-64339712019-04-02 Past, Present, and Future Strategies for Enhanced Assessment of Embryo's Genome and Reproductive Competence in Women of Advanced Reproductive Age Poli, Maurizio Girardi, Laura Fabiani, Marco Moretto, Martina Romanelli, Valeria Patassini, Cristina Zuccarello, Daniela Capalbo, Antonio Front Endocrinol (Lausanne) Endocrinology Recent advancements in genomic analysis allow testing of an increasing number of genetic features in human preimplantation embryos. Typical single gene mutation and whole chromosomes testing can now be integrated with assessment of mitochondrial DNA and polygenic conditions. Diagnostic expansion into epigenetic and transcriptomic assessment in the near future are potential technological targets which may improve the prognostic outlook of patients of advanced reproductive age and overall in vitro fertilization (IVF) treatment outcomes. In this review, we discuss the technological progress of recent years and their future applications in preimplantation genetic testing in IVF. Frontiers Media S.A. 2019-03-19 /pmc/articles/PMC6433971/ /pubmed/30941103 http://dx.doi.org/10.3389/fendo.2019.00154 Text en Copyright © 2019 Poli, Girardi, Fabiani, Moretto, Romanelli, Patassini, Zuccarello and Capalbo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Poli, Maurizio
Girardi, Laura
Fabiani, Marco
Moretto, Martina
Romanelli, Valeria
Patassini, Cristina
Zuccarello, Daniela
Capalbo, Antonio
Past, Present, and Future Strategies for Enhanced Assessment of Embryo's Genome and Reproductive Competence in Women of Advanced Reproductive Age
title Past, Present, and Future Strategies for Enhanced Assessment of Embryo's Genome and Reproductive Competence in Women of Advanced Reproductive Age
title_full Past, Present, and Future Strategies for Enhanced Assessment of Embryo's Genome and Reproductive Competence in Women of Advanced Reproductive Age
title_fullStr Past, Present, and Future Strategies for Enhanced Assessment of Embryo's Genome and Reproductive Competence in Women of Advanced Reproductive Age
title_full_unstemmed Past, Present, and Future Strategies for Enhanced Assessment of Embryo's Genome and Reproductive Competence in Women of Advanced Reproductive Age
title_short Past, Present, and Future Strategies for Enhanced Assessment of Embryo's Genome and Reproductive Competence in Women of Advanced Reproductive Age
title_sort past, present, and future strategies for enhanced assessment of embryo's genome and reproductive competence in women of advanced reproductive age
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433971/
https://www.ncbi.nlm.nih.gov/pubmed/30941103
http://dx.doi.org/10.3389/fendo.2019.00154
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