Potassium chloride released from contracting skeletal muscle may stimulate development of its hypertrophy

The effects of potassium chloride on the expression of IGF-1 splice forms and myoblast proliferation were investigated. KCl at the concentrations of 7–12 mM stimulated the synthesis of IGF-1 and mechano growth factor (MGF) in murine myoblasts as well as in myotubes both at the mRNA and protein level...

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Detalles Bibliográficos
Autores principales: Kravchenko, Irina V., Furalyov, Vladimir A., Popov, Vladimir O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433999/
https://www.ncbi.nlm.nih.gov/pubmed/30957033
http://dx.doi.org/10.1016/j.bbrep.2019.100627
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author Kravchenko, Irina V.
Furalyov, Vladimir A.
Popov, Vladimir O.
author_facet Kravchenko, Irina V.
Furalyov, Vladimir A.
Popov, Vladimir O.
author_sort Kravchenko, Irina V.
collection PubMed
description The effects of potassium chloride on the expression of IGF-1 splice forms and myoblast proliferation were investigated. KCl at the concentrations of 7–12 mM stimulated the synthesis of IGF-1 and mechano growth factor (MGF) in murine myoblasts as well as in myotubes both at the mRNA and protein levels. Pan-calcium channel blocker CdCl(2) completely abolished stimulation of growth factor expression, whereas blocker of HCN and Na(v)1.4 channels ZD7288 drastically reduced it. In addition, potassium chloride stimulated myoblast proliferation, while IGF-1 autocrine signaling inhibition partially suppressed these mitogenic effects.
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spelling pubmed-64339992019-04-05 Potassium chloride released from contracting skeletal muscle may stimulate development of its hypertrophy Kravchenko, Irina V. Furalyov, Vladimir A. Popov, Vladimir O. Biochem Biophys Rep Research Article The effects of potassium chloride on the expression of IGF-1 splice forms and myoblast proliferation were investigated. KCl at the concentrations of 7–12 mM stimulated the synthesis of IGF-1 and mechano growth factor (MGF) in murine myoblasts as well as in myotubes both at the mRNA and protein levels. Pan-calcium channel blocker CdCl(2) completely abolished stimulation of growth factor expression, whereas blocker of HCN and Na(v)1.4 channels ZD7288 drastically reduced it. In addition, potassium chloride stimulated myoblast proliferation, while IGF-1 autocrine signaling inhibition partially suppressed these mitogenic effects. Elsevier 2019-03-21 /pmc/articles/PMC6433999/ /pubmed/30957033 http://dx.doi.org/10.1016/j.bbrep.2019.100627 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Kravchenko, Irina V.
Furalyov, Vladimir A.
Popov, Vladimir O.
Potassium chloride released from contracting skeletal muscle may stimulate development of its hypertrophy
title Potassium chloride released from contracting skeletal muscle may stimulate development of its hypertrophy
title_full Potassium chloride released from contracting skeletal muscle may stimulate development of its hypertrophy
title_fullStr Potassium chloride released from contracting skeletal muscle may stimulate development of its hypertrophy
title_full_unstemmed Potassium chloride released from contracting skeletal muscle may stimulate development of its hypertrophy
title_short Potassium chloride released from contracting skeletal muscle may stimulate development of its hypertrophy
title_sort potassium chloride released from contracting skeletal muscle may stimulate development of its hypertrophy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433999/
https://www.ncbi.nlm.nih.gov/pubmed/30957033
http://dx.doi.org/10.1016/j.bbrep.2019.100627
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