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Dyslexia and age related effects in the neurometabolites concentration in the visual and temporo-parietal cortex

Several etiological theories, in particular neuronal noise and impaired auditory sampling, predicted neurotransmission deficits in dyslexia. Neurometabolites also affect white matter microstructure, where abnormalities were previously reported in dyslexia. However findings from only few magnetic res...

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Autores principales: Kossowski, Bartosz, Chyl, Katarzyna, Kacprzak, Agnieszka, Bogorodzki, Piotr, Jednoróg, Katarzyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434036/
https://www.ncbi.nlm.nih.gov/pubmed/30911032
http://dx.doi.org/10.1038/s41598-019-41473-x
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author Kossowski, Bartosz
Chyl, Katarzyna
Kacprzak, Agnieszka
Bogorodzki, Piotr
Jednoróg, Katarzyna
author_facet Kossowski, Bartosz
Chyl, Katarzyna
Kacprzak, Agnieszka
Bogorodzki, Piotr
Jednoróg, Katarzyna
author_sort Kossowski, Bartosz
collection PubMed
description Several etiological theories, in particular neuronal noise and impaired auditory sampling, predicted neurotransmission deficits in dyslexia. Neurometabolites also affect white matter microstructure, where abnormalities were previously reported in dyslexia. However findings from only few magnetic resonance spectroscopy studies using diverse age groups, different brain regions, data processing and reference scaling are inconsistent. We used MEGA-PRESS single-voxel spectroscopy in two ROIs: left temporo-parietal and occipital cortex in 36 adults and 52 children, where half in each group had dyslexia. Dyslexics, on average, had significantly lower total N-acetylaspartate (tNAA) than controls in the occipital cortex. Adults compared to children were characterized by higher choline and creatine in both areas, higher tNAA in left temporo-parietal and lower glutamate in the visual cortex, reflecting maturational changes in cortical microstructure and metabolism. Although the current findings do not support the proposed etiological theories of dyslexia, they show, for the first time, that tNAA, considered to be a neurochemical correlate of white matter integrity, is deficient in the visual cortex in both children and adults with dyslexia. They also point that several neurotransmitters, including ones previously used as reference, change with age.
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spelling pubmed-64340362019-04-02 Dyslexia and age related effects in the neurometabolites concentration in the visual and temporo-parietal cortex Kossowski, Bartosz Chyl, Katarzyna Kacprzak, Agnieszka Bogorodzki, Piotr Jednoróg, Katarzyna Sci Rep Article Several etiological theories, in particular neuronal noise and impaired auditory sampling, predicted neurotransmission deficits in dyslexia. Neurometabolites also affect white matter microstructure, where abnormalities were previously reported in dyslexia. However findings from only few magnetic resonance spectroscopy studies using diverse age groups, different brain regions, data processing and reference scaling are inconsistent. We used MEGA-PRESS single-voxel spectroscopy in two ROIs: left temporo-parietal and occipital cortex in 36 adults and 52 children, where half in each group had dyslexia. Dyslexics, on average, had significantly lower total N-acetylaspartate (tNAA) than controls in the occipital cortex. Adults compared to children were characterized by higher choline and creatine in both areas, higher tNAA in left temporo-parietal and lower glutamate in the visual cortex, reflecting maturational changes in cortical microstructure and metabolism. Although the current findings do not support the proposed etiological theories of dyslexia, they show, for the first time, that tNAA, considered to be a neurochemical correlate of white matter integrity, is deficient in the visual cortex in both children and adults with dyslexia. They also point that several neurotransmitters, including ones previously used as reference, change with age. Nature Publishing Group UK 2019-03-25 /pmc/articles/PMC6434036/ /pubmed/30911032 http://dx.doi.org/10.1038/s41598-019-41473-x Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kossowski, Bartosz
Chyl, Katarzyna
Kacprzak, Agnieszka
Bogorodzki, Piotr
Jednoróg, Katarzyna
Dyslexia and age related effects in the neurometabolites concentration in the visual and temporo-parietal cortex
title Dyslexia and age related effects in the neurometabolites concentration in the visual and temporo-parietal cortex
title_full Dyslexia and age related effects in the neurometabolites concentration in the visual and temporo-parietal cortex
title_fullStr Dyslexia and age related effects in the neurometabolites concentration in the visual and temporo-parietal cortex
title_full_unstemmed Dyslexia and age related effects in the neurometabolites concentration in the visual and temporo-parietal cortex
title_short Dyslexia and age related effects in the neurometabolites concentration in the visual and temporo-parietal cortex
title_sort dyslexia and age related effects in the neurometabolites concentration in the visual and temporo-parietal cortex
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434036/
https://www.ncbi.nlm.nih.gov/pubmed/30911032
http://dx.doi.org/10.1038/s41598-019-41473-x
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