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(D)-Serine reflects kidney function and diseases

(D)-Amino acids, long-term undetected enantiomers of (L)-amino acids, are now emerging as potential biomarkers, especially for kidney diseases. Management of chronic kidney disease (CKD), a global problem with its high prevalence and poor prognosis, is currently unsatisfactory due to the difficulty...

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Autores principales: Hesaka, Atsushi, Sakai, Shinsuke, Hamase, Kenji, Ikeda, Tatsuhiko, Matsui, Rakan, Mita, Masashi, Horio, Masaru, Isaka, Yoshitaka, Kimura, Tomonori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434045/
https://www.ncbi.nlm.nih.gov/pubmed/30911057
http://dx.doi.org/10.1038/s41598-019-41608-0
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author Hesaka, Atsushi
Sakai, Shinsuke
Hamase, Kenji
Ikeda, Tatsuhiko
Matsui, Rakan
Mita, Masashi
Horio, Masaru
Isaka, Yoshitaka
Kimura, Tomonori
author_facet Hesaka, Atsushi
Sakai, Shinsuke
Hamase, Kenji
Ikeda, Tatsuhiko
Matsui, Rakan
Mita, Masashi
Horio, Masaru
Isaka, Yoshitaka
Kimura, Tomonori
author_sort Hesaka, Atsushi
collection PubMed
description (D)-Amino acids, long-term undetected enantiomers of (L)-amino acids, are now emerging as potential biomarkers, especially for kidney diseases. Management of chronic kidney disease (CKD), a global problem with its high prevalence and poor prognosis, is currently unsatisfactory due to the difficulty in estimating kidney function and in early detection of diseases. We now show that intra-body dynamics of (D)-serine reflect kidney function and diseases. The blood level of (D)-serine correlated well with the actual glomerular filtration ratio, a key kidney function. This correlation was compatible with those of conventional kidney markers, and blood level of (D)-serine was relatively unaffected by such clinical factors as body size. The balance between excretion and reabsorption of amino acids by the kidney was controlled with chiral selectivity, and the reabsorption of (D)-serine was sensitive to the presence of CKD. The combination of blood level and urinary dynamics of (D)-serine effectively distinguished CKD from non-CKD. These lines of evidence provide new insights into the enantioselective amino acid dynamics in the human body that reflect disease pathophysiology. (D)-Serine may serve as a vital biomarker that suppress CKD onset through the precise assessment of kidney function and the diagnosis of CKD.
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spelling pubmed-64340452019-04-02 (D)-Serine reflects kidney function and diseases Hesaka, Atsushi Sakai, Shinsuke Hamase, Kenji Ikeda, Tatsuhiko Matsui, Rakan Mita, Masashi Horio, Masaru Isaka, Yoshitaka Kimura, Tomonori Sci Rep Article (D)-Amino acids, long-term undetected enantiomers of (L)-amino acids, are now emerging as potential biomarkers, especially for kidney diseases. Management of chronic kidney disease (CKD), a global problem with its high prevalence and poor prognosis, is currently unsatisfactory due to the difficulty in estimating kidney function and in early detection of diseases. We now show that intra-body dynamics of (D)-serine reflect kidney function and diseases. The blood level of (D)-serine correlated well with the actual glomerular filtration ratio, a key kidney function. This correlation was compatible with those of conventional kidney markers, and blood level of (D)-serine was relatively unaffected by such clinical factors as body size. The balance between excretion and reabsorption of amino acids by the kidney was controlled with chiral selectivity, and the reabsorption of (D)-serine was sensitive to the presence of CKD. The combination of blood level and urinary dynamics of (D)-serine effectively distinguished CKD from non-CKD. These lines of evidence provide new insights into the enantioselective amino acid dynamics in the human body that reflect disease pathophysiology. (D)-Serine may serve as a vital biomarker that suppress CKD onset through the precise assessment of kidney function and the diagnosis of CKD. Nature Publishing Group UK 2019-03-25 /pmc/articles/PMC6434045/ /pubmed/30911057 http://dx.doi.org/10.1038/s41598-019-41608-0 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Hesaka, Atsushi
Sakai, Shinsuke
Hamase, Kenji
Ikeda, Tatsuhiko
Matsui, Rakan
Mita, Masashi
Horio, Masaru
Isaka, Yoshitaka
Kimura, Tomonori
(D)-Serine reflects kidney function and diseases
title (D)-Serine reflects kidney function and diseases
title_full (D)-Serine reflects kidney function and diseases
title_fullStr (D)-Serine reflects kidney function and diseases
title_full_unstemmed (D)-Serine reflects kidney function and diseases
title_short (D)-Serine reflects kidney function and diseases
title_sort (d)-serine reflects kidney function and diseases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434045/
https://www.ncbi.nlm.nih.gov/pubmed/30911057
http://dx.doi.org/10.1038/s41598-019-41608-0
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