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Magnetic resonance imaging of brain cell water
In the central nervous system of vertebrates, cell bodies of neurons are often assembled as nuclei or cellular layers that play specific roles as functional units. The purpose of this work was to selectively highlight such cell assemblies by magnetic resonance imaging using signals from water proton...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434048/ https://www.ncbi.nlm.nih.gov/pubmed/30911100 http://dx.doi.org/10.1038/s41598-019-41587-2 |
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author | Watanabe, Takashi Wang, Xiaoqing Tan, Zhengguo Frahm, Jens |
author_facet | Watanabe, Takashi Wang, Xiaoqing Tan, Zhengguo Frahm, Jens |
author_sort | Watanabe, Takashi |
collection | PubMed |
description | In the central nervous system of vertebrates, cell bodies of neurons are often assembled as nuclei or cellular layers that play specific roles as functional units. The purpose of this work was to selectively highlight such cell assemblies by magnetic resonance imaging using signals from water protons that are associated with intracellular paramagnetic ions, while saturating lipid-associated water protons as well as extracellular free water protons. Given the significant correlation between image signal intensity and water proton density, the high signal intensities observed for such cell assemblies must be attributed to their abundant paramagnetic-ion-associated water protons. In the hippocampal formation, the technique visualized cell assemblies that were so far not depicted in human in vivo. In the brainstem, the technique delineated noradrenergic neuron groups such as the locus coeruleus in human and mice in vivo. Their reduced magnetization-transfer ratios together with their prolonged relaxation times compared to other gray matter indicate that the source of their high signal intensity is not the presence of T(1)-shortening molecules, e.g., neuromelanin, but their high water content. Given the general absence of neuromelanin in noradrenergic neurons of rodents, their high signal intensity in mice in vivo further supports this view. |
format | Online Article Text |
id | pubmed-6434048 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-64340482019-04-02 Magnetic resonance imaging of brain cell water Watanabe, Takashi Wang, Xiaoqing Tan, Zhengguo Frahm, Jens Sci Rep Article In the central nervous system of vertebrates, cell bodies of neurons are often assembled as nuclei or cellular layers that play specific roles as functional units. The purpose of this work was to selectively highlight such cell assemblies by magnetic resonance imaging using signals from water protons that are associated with intracellular paramagnetic ions, while saturating lipid-associated water protons as well as extracellular free water protons. Given the significant correlation between image signal intensity and water proton density, the high signal intensities observed for such cell assemblies must be attributed to their abundant paramagnetic-ion-associated water protons. In the hippocampal formation, the technique visualized cell assemblies that were so far not depicted in human in vivo. In the brainstem, the technique delineated noradrenergic neuron groups such as the locus coeruleus in human and mice in vivo. Their reduced magnetization-transfer ratios together with their prolonged relaxation times compared to other gray matter indicate that the source of their high signal intensity is not the presence of T(1)-shortening molecules, e.g., neuromelanin, but their high water content. Given the general absence of neuromelanin in noradrenergic neurons of rodents, their high signal intensity in mice in vivo further supports this view. Nature Publishing Group UK 2019-03-25 /pmc/articles/PMC6434048/ /pubmed/30911100 http://dx.doi.org/10.1038/s41598-019-41587-2 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Watanabe, Takashi Wang, Xiaoqing Tan, Zhengguo Frahm, Jens Magnetic resonance imaging of brain cell water |
title | Magnetic resonance imaging of brain cell water |
title_full | Magnetic resonance imaging of brain cell water |
title_fullStr | Magnetic resonance imaging of brain cell water |
title_full_unstemmed | Magnetic resonance imaging of brain cell water |
title_short | Magnetic resonance imaging of brain cell water |
title_sort | magnetic resonance imaging of brain cell water |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434048/ https://www.ncbi.nlm.nih.gov/pubmed/30911100 http://dx.doi.org/10.1038/s41598-019-41587-2 |
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