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Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice
Over the past few decades, there has been growing interest in understanding the molecular mechanisms of cancer pathogenesis and progression, as it is still associated with high morbidity and mortality. Current management of large bone sarcomas typically includes the complex therapeutic approach of l...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434099/ https://www.ncbi.nlm.nih.gov/pubmed/30956944 http://dx.doi.org/10.1016/j.jbo.2019.100231 |
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author | Stamatopoulos, Alexandros Stamatopoulos, Theodosios Gamie, Zakareya Kenanidis, Eustathios Ribeiro, Ricardo Da Conceicao Rankin, Kenneth Samora Gerrand, Craig Dalgarno, Kenneth Tsiridis, Eleftherios |
author_facet | Stamatopoulos, Alexandros Stamatopoulos, Theodosios Gamie, Zakareya Kenanidis, Eustathios Ribeiro, Ricardo Da Conceicao Rankin, Kenneth Samora Gerrand, Craig Dalgarno, Kenneth Tsiridis, Eleftherios |
author_sort | Stamatopoulos, Alexandros |
collection | PubMed |
description | Over the past few decades, there has been growing interest in understanding the molecular mechanisms of cancer pathogenesis and progression, as it is still associated with high morbidity and mortality. Current management of large bone sarcomas typically includes the complex therapeutic approach of limb salvage or sacrifice combined with pre- and postoperative multidrug chemotherapy and/or radiotherapy, and is still associated with high recurrence rates. The development of cellular strategies against specific characteristics of tumour cells appears to be promising, as they can target cancer cells selectively. Recently, Mesenchymal Stromal Cells (MSCs) have been the subject of significant research in orthopaedic clinical practice through their use in regenerative medicine. Further research has been directed at the use of MSCs for more personalized bone sarcoma treatments, taking advantage of their wide range of potential biological functions, which can be augmented by using tissue engineering approaches to promote healing of large defects. In this review, we explore the use of MSCs in bone sarcoma treatment, by analyzing MSCs and tumour cell interactions, transduction of MSCs to target sarcoma, and their clinical applications on humans concerning bone regeneration after bone sarcoma extraction. |
format | Online Article Text |
id | pubmed-6434099 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-64340992019-04-05 Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice Stamatopoulos, Alexandros Stamatopoulos, Theodosios Gamie, Zakareya Kenanidis, Eustathios Ribeiro, Ricardo Da Conceicao Rankin, Kenneth Samora Gerrand, Craig Dalgarno, Kenneth Tsiridis, Eleftherios J Bone Oncol Review Article Over the past few decades, there has been growing interest in understanding the molecular mechanisms of cancer pathogenesis and progression, as it is still associated with high morbidity and mortality. Current management of large bone sarcomas typically includes the complex therapeutic approach of limb salvage or sacrifice combined with pre- and postoperative multidrug chemotherapy and/or radiotherapy, and is still associated with high recurrence rates. The development of cellular strategies against specific characteristics of tumour cells appears to be promising, as they can target cancer cells selectively. Recently, Mesenchymal Stromal Cells (MSCs) have been the subject of significant research in orthopaedic clinical practice through their use in regenerative medicine. Further research has been directed at the use of MSCs for more personalized bone sarcoma treatments, taking advantage of their wide range of potential biological functions, which can be augmented by using tissue engineering approaches to promote healing of large defects. In this review, we explore the use of MSCs in bone sarcoma treatment, by analyzing MSCs and tumour cell interactions, transduction of MSCs to target sarcoma, and their clinical applications on humans concerning bone regeneration after bone sarcoma extraction. Elsevier 2019-03-19 /pmc/articles/PMC6434099/ /pubmed/30956944 http://dx.doi.org/10.1016/j.jbo.2019.100231 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Stamatopoulos, Alexandros Stamatopoulos, Theodosios Gamie, Zakareya Kenanidis, Eustathios Ribeiro, Ricardo Da Conceicao Rankin, Kenneth Samora Gerrand, Craig Dalgarno, Kenneth Tsiridis, Eleftherios Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice |
title | Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice |
title_full | Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice |
title_fullStr | Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice |
title_full_unstemmed | Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice |
title_short | Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice |
title_sort | mesenchymal stromal cells for bone sarcoma treatment: roadmap to clinical practice |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434099/ https://www.ncbi.nlm.nih.gov/pubmed/30956944 http://dx.doi.org/10.1016/j.jbo.2019.100231 |
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