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Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice

Over the past few decades, there has been growing interest in understanding the molecular mechanisms of cancer pathogenesis and progression, as it is still associated with high morbidity and mortality. Current management of large bone sarcomas typically includes the complex therapeutic approach of l...

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Autores principales: Stamatopoulos, Alexandros, Stamatopoulos, Theodosios, Gamie, Zakareya, Kenanidis, Eustathios, Ribeiro, Ricardo Da Conceicao, Rankin, Kenneth Samora, Gerrand, Craig, Dalgarno, Kenneth, Tsiridis, Eleftherios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434099/
https://www.ncbi.nlm.nih.gov/pubmed/30956944
http://dx.doi.org/10.1016/j.jbo.2019.100231
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author Stamatopoulos, Alexandros
Stamatopoulos, Theodosios
Gamie, Zakareya
Kenanidis, Eustathios
Ribeiro, Ricardo Da Conceicao
Rankin, Kenneth Samora
Gerrand, Craig
Dalgarno, Kenneth
Tsiridis, Eleftherios
author_facet Stamatopoulos, Alexandros
Stamatopoulos, Theodosios
Gamie, Zakareya
Kenanidis, Eustathios
Ribeiro, Ricardo Da Conceicao
Rankin, Kenneth Samora
Gerrand, Craig
Dalgarno, Kenneth
Tsiridis, Eleftherios
author_sort Stamatopoulos, Alexandros
collection PubMed
description Over the past few decades, there has been growing interest in understanding the molecular mechanisms of cancer pathogenesis and progression, as it is still associated with high morbidity and mortality. Current management of large bone sarcomas typically includes the complex therapeutic approach of limb salvage or sacrifice combined with pre- and postoperative multidrug chemotherapy and/or radiotherapy, and is still associated with high recurrence rates. The development of cellular strategies against specific characteristics of tumour cells appears to be promising, as they can target cancer cells selectively. Recently, Mesenchymal Stromal Cells (MSCs) have been the subject of significant research in orthopaedic clinical practice through their use in regenerative medicine. Further research has been directed at the use of MSCs for more personalized bone sarcoma treatments, taking advantage of their wide range of potential biological functions, which can be augmented by using tissue engineering approaches to promote healing of large defects. In this review, we explore the use of MSCs in bone sarcoma treatment, by analyzing MSCs and tumour cell interactions, transduction of MSCs to target sarcoma, and their clinical applications on humans concerning bone regeneration after bone sarcoma extraction.
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spelling pubmed-64340992019-04-05 Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice Stamatopoulos, Alexandros Stamatopoulos, Theodosios Gamie, Zakareya Kenanidis, Eustathios Ribeiro, Ricardo Da Conceicao Rankin, Kenneth Samora Gerrand, Craig Dalgarno, Kenneth Tsiridis, Eleftherios J Bone Oncol Review Article Over the past few decades, there has been growing interest in understanding the molecular mechanisms of cancer pathogenesis and progression, as it is still associated with high morbidity and mortality. Current management of large bone sarcomas typically includes the complex therapeutic approach of limb salvage or sacrifice combined with pre- and postoperative multidrug chemotherapy and/or radiotherapy, and is still associated with high recurrence rates. The development of cellular strategies against specific characteristics of tumour cells appears to be promising, as they can target cancer cells selectively. Recently, Mesenchymal Stromal Cells (MSCs) have been the subject of significant research in orthopaedic clinical practice through their use in regenerative medicine. Further research has been directed at the use of MSCs for more personalized bone sarcoma treatments, taking advantage of their wide range of potential biological functions, which can be augmented by using tissue engineering approaches to promote healing of large defects. In this review, we explore the use of MSCs in bone sarcoma treatment, by analyzing MSCs and tumour cell interactions, transduction of MSCs to target sarcoma, and their clinical applications on humans concerning bone regeneration after bone sarcoma extraction. Elsevier 2019-03-19 /pmc/articles/PMC6434099/ /pubmed/30956944 http://dx.doi.org/10.1016/j.jbo.2019.100231 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Stamatopoulos, Alexandros
Stamatopoulos, Theodosios
Gamie, Zakareya
Kenanidis, Eustathios
Ribeiro, Ricardo Da Conceicao
Rankin, Kenneth Samora
Gerrand, Craig
Dalgarno, Kenneth
Tsiridis, Eleftherios
Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice
title Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice
title_full Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice
title_fullStr Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice
title_full_unstemmed Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice
title_short Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice
title_sort mesenchymal stromal cells for bone sarcoma treatment: roadmap to clinical practice
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434099/
https://www.ncbi.nlm.nih.gov/pubmed/30956944
http://dx.doi.org/10.1016/j.jbo.2019.100231
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