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CACNA1C risk variant affects microstructural connectivity of the amygdala

Deficits in perception of emotional prosody have been described in patients with affective disorders at behavioral and neural level. In the current study, we use an imaging genetics approach to examine the impact of CACNA1C, one of the most promising genetic risk factors for psychiatric disorders, o...

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Autores principales: Koch, Katharina, Stegmaier, Sophia, Schwarz, Lena, Erb, Michael, Thomas, Mara, Scheffler, Klaus, Wildgruber, Dirk, Nieratschker, Vanessa, Ethofer, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434179/
https://www.ncbi.nlm.nih.gov/pubmed/30909026
http://dx.doi.org/10.1016/j.nicl.2019.101774
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author Koch, Katharina
Stegmaier, Sophia
Schwarz, Lena
Erb, Michael
Thomas, Mara
Scheffler, Klaus
Wildgruber, Dirk
Nieratschker, Vanessa
Ethofer, Thomas
author_facet Koch, Katharina
Stegmaier, Sophia
Schwarz, Lena
Erb, Michael
Thomas, Mara
Scheffler, Klaus
Wildgruber, Dirk
Nieratschker, Vanessa
Ethofer, Thomas
author_sort Koch, Katharina
collection PubMed
description Deficits in perception of emotional prosody have been described in patients with affective disorders at behavioral and neural level. In the current study, we use an imaging genetics approach to examine the impact of CACNA1C, one of the most promising genetic risk factors for psychiatric disorders, on prosody processing on a behavioral, functional and microstructural level. Using functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) we examined key areas involved in prosody processing, i.e. the amygdala and voice areas, in a healthy population. We found stronger activation to emotional than neutral prosody in the voice areas and the amygdala, but CACNA1C rs1006737 genotype had no influence on fMRI activity. However, significant microstructural differences (i.e. mean diffusivity) between CACNA1C rs1006737 risk allele carriers and non carriers were found in the amygdala, but not the voice areas. These modifications in brain architecture associated with CACNA1C might reflect a neurobiological marker predisposing to affective disorders and concomitant alterations in emotion perception.
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spelling pubmed-64341792019-04-08 CACNA1C risk variant affects microstructural connectivity of the amygdala Koch, Katharina Stegmaier, Sophia Schwarz, Lena Erb, Michael Thomas, Mara Scheffler, Klaus Wildgruber, Dirk Nieratschker, Vanessa Ethofer, Thomas Neuroimage Clin Regular Article Deficits in perception of emotional prosody have been described in patients with affective disorders at behavioral and neural level. In the current study, we use an imaging genetics approach to examine the impact of CACNA1C, one of the most promising genetic risk factors for psychiatric disorders, on prosody processing on a behavioral, functional and microstructural level. Using functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) we examined key areas involved in prosody processing, i.e. the amygdala and voice areas, in a healthy population. We found stronger activation to emotional than neutral prosody in the voice areas and the amygdala, but CACNA1C rs1006737 genotype had no influence on fMRI activity. However, significant microstructural differences (i.e. mean diffusivity) between CACNA1C rs1006737 risk allele carriers and non carriers were found in the amygdala, but not the voice areas. These modifications in brain architecture associated with CACNA1C might reflect a neurobiological marker predisposing to affective disorders and concomitant alterations in emotion perception. Elsevier 2019-03-12 /pmc/articles/PMC6434179/ /pubmed/30909026 http://dx.doi.org/10.1016/j.nicl.2019.101774 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Koch, Katharina
Stegmaier, Sophia
Schwarz, Lena
Erb, Michael
Thomas, Mara
Scheffler, Klaus
Wildgruber, Dirk
Nieratschker, Vanessa
Ethofer, Thomas
CACNA1C risk variant affects microstructural connectivity of the amygdala
title CACNA1C risk variant affects microstructural connectivity of the amygdala
title_full CACNA1C risk variant affects microstructural connectivity of the amygdala
title_fullStr CACNA1C risk variant affects microstructural connectivity of the amygdala
title_full_unstemmed CACNA1C risk variant affects microstructural connectivity of the amygdala
title_short CACNA1C risk variant affects microstructural connectivity of the amygdala
title_sort cacna1c risk variant affects microstructural connectivity of the amygdala
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434179/
https://www.ncbi.nlm.nih.gov/pubmed/30909026
http://dx.doi.org/10.1016/j.nicl.2019.101774
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