Peperomin E and its orally bioavailable analog induce oxidative stress-mediated apoptosis of acute myeloid leukemia progenitor cells by targeting thioredoxin reductase

The early immature CD34(+) acute myeloid leukemia (AML) cell subpopulation-acute myeloid leukemia progenitor cells (APCs), is often resistant to conventional chemotherapy, making them largely responsible for the relapse of AML. However, to date, the eradication of APCs remains a major challenge. We...

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Detalles Bibliográficos
Autores principales: Wang, Xinzhi, Gao, Ming, Zhang, Jiyun, Ma, Ying, Qu, Wenshu, Liang, Jingyu, Wu, Hao, Wen, Hongmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434189/
https://www.ncbi.nlm.nih.gov/pubmed/30909158
http://dx.doi.org/10.1016/j.redox.2019.101153

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