Serum folate receptor α (sFR) in ovarian cancer diagnosis and surveillance

Novelty and Impact Statement: Our findings suggest that soluble folate receptor (sFR) could be used in both the initial diagnosis and surveillance of patients with ovarian cancer. Our cohort constitutes one of the largest comparison groups for sFR analyzed so far. We have defined the background leve...

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Detalles Bibliográficos
Autores principales: Farran, Batoul, Albayrak, Samet, Abrams, Judith, Tainsky, Michael A., Levin, Nancy K., Morris, Robert, Matherly, Larry H., Ratnam, Manohar, Winer, Ira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Clinical Cancer Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434204/
https://www.ncbi.nlm.nih.gov/pubmed/30761774
http://dx.doi.org/10.1002/cam4.1944
Descripción
Sumario:Novelty and Impact Statement: Our findings suggest that soluble folate receptor (sFR) could be used in both the initial diagnosis and surveillance of patients with ovarian cancer. Our cohort constitutes one of the largest comparison groups for sFR analyzed so far. We have defined the background level of sFR using healthy volunteers. This is also the first study to prospectively follow patients in the surveillance setting to concurrently identify differential changes in tumor markers CA‐125 and sFR.

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