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Photobiomodulation and Coenzyme Q(10) Treatments Attenuate Cognitive Impairment Associated With Model of Transient Global Brain Ischemia in Artificially Aged Mice

Disturbances in mitochondrial biogenesis and bioenergetics, combined with neuroinflammation, play cardinal roles in the cognitive impairment during aging that is further exacerbated by transient cerebral ischemia. Both near-infrared (NIR) photobiomodulation (PBM) and Coenzyme Q(10) (CoQ(10)) adminis...

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Autores principales: Salehpour, Farzad, Farajdokht, Fereshteh, Mahmoudi, Javad, Erfani, Marjan, Farhoudi, Mehdi, Karimi, Pouran, Rasta, Seyed Hossein, Sadigh-Eteghad, Saeed, Hamblin, Michael R., Gjedde, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434313/
https://www.ncbi.nlm.nih.gov/pubmed/30983970
http://dx.doi.org/10.3389/fncel.2019.00074
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author Salehpour, Farzad
Farajdokht, Fereshteh
Mahmoudi, Javad
Erfani, Marjan
Farhoudi, Mehdi
Karimi, Pouran
Rasta, Seyed Hossein
Sadigh-Eteghad, Saeed
Hamblin, Michael R.
Gjedde, Albert
author_facet Salehpour, Farzad
Farajdokht, Fereshteh
Mahmoudi, Javad
Erfani, Marjan
Farhoudi, Mehdi
Karimi, Pouran
Rasta, Seyed Hossein
Sadigh-Eteghad, Saeed
Hamblin, Michael R.
Gjedde, Albert
author_sort Salehpour, Farzad
collection PubMed
description Disturbances in mitochondrial biogenesis and bioenergetics, combined with neuroinflammation, play cardinal roles in the cognitive impairment during aging that is further exacerbated by transient cerebral ischemia. Both near-infrared (NIR) photobiomodulation (PBM) and Coenzyme Q(10) (CoQ(10)) administration are known to stimulate mitochondrial electron transport that potentially may reverse the effects of cerebral ischemia in aged animals. We tested the hypothesis that the effects of PBM and CoQ(10), separately or in combination, improve cognition in a mouse model of transient cerebral ischemia superimposed on a model of aging. We modeled aging by 6-week administration of D-galactose (500 mg/kg subcutaneous) to mice. We subsequently induced transient cerebral ischemia by bilateral occlusion of the common carotid artery (BCCAO). We treated the mice with PBM (810 nm transcranial laser) or CoQ(10) (500 mg/kg by gavage), or both, for 2 weeks after surgery. We assessed cognitive function by the Barnes and Lashley III mazes and the What-Where-Which (WWWhich) task. PBM or CoQ(10), and both, improved spatial and episodic memory in the mice. Separately and together, the treatments lowered reactive oxygen species and raised ATP and general mitochondrial activity as well as biomarkers of mitochondrial biogenesis, including SIRT1, PGC-1α, NRF1, and TFAM. Neuroinflammatory responsiveness declined, as indicated by decreased iNOS, TNF-α, and IL-1β levels with the PBM and CoQ(10) treatments. Collectively, the findings of this preclinical study imply that the procognitive effects of NIR PBM and CoQ(10) treatments, separately or in combination, are beneficial in a model of transient global brain ischemia superimposed on a model of aging in mice.
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spelling pubmed-64343132019-04-12 Photobiomodulation and Coenzyme Q(10) Treatments Attenuate Cognitive Impairment Associated With Model of Transient Global Brain Ischemia in Artificially Aged Mice Salehpour, Farzad Farajdokht, Fereshteh Mahmoudi, Javad Erfani, Marjan Farhoudi, Mehdi Karimi, Pouran Rasta, Seyed Hossein Sadigh-Eteghad, Saeed Hamblin, Michael R. Gjedde, Albert Front Cell Neurosci Neuroscience Disturbances in mitochondrial biogenesis and bioenergetics, combined with neuroinflammation, play cardinal roles in the cognitive impairment during aging that is further exacerbated by transient cerebral ischemia. Both near-infrared (NIR) photobiomodulation (PBM) and Coenzyme Q(10) (CoQ(10)) administration are known to stimulate mitochondrial electron transport that potentially may reverse the effects of cerebral ischemia in aged animals. We tested the hypothesis that the effects of PBM and CoQ(10), separately or in combination, improve cognition in a mouse model of transient cerebral ischemia superimposed on a model of aging. We modeled aging by 6-week administration of D-galactose (500 mg/kg subcutaneous) to mice. We subsequently induced transient cerebral ischemia by bilateral occlusion of the common carotid artery (BCCAO). We treated the mice with PBM (810 nm transcranial laser) or CoQ(10) (500 mg/kg by gavage), or both, for 2 weeks after surgery. We assessed cognitive function by the Barnes and Lashley III mazes and the What-Where-Which (WWWhich) task. PBM or CoQ(10), and both, improved spatial and episodic memory in the mice. Separately and together, the treatments lowered reactive oxygen species and raised ATP and general mitochondrial activity as well as biomarkers of mitochondrial biogenesis, including SIRT1, PGC-1α, NRF1, and TFAM. Neuroinflammatory responsiveness declined, as indicated by decreased iNOS, TNF-α, and IL-1β levels with the PBM and CoQ(10) treatments. Collectively, the findings of this preclinical study imply that the procognitive effects of NIR PBM and CoQ(10) treatments, separately or in combination, are beneficial in a model of transient global brain ischemia superimposed on a model of aging in mice. Frontiers Media S.A. 2019-03-19 /pmc/articles/PMC6434313/ /pubmed/30983970 http://dx.doi.org/10.3389/fncel.2019.00074 Text en Copyright © 2019 Salehpour, Farajdokht, Mahmoudi, Erfani, Farhoudi, Karimi, Rasta, Sadigh-Eteghad, Hamblin and Gjedde. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Salehpour, Farzad
Farajdokht, Fereshteh
Mahmoudi, Javad
Erfani, Marjan
Farhoudi, Mehdi
Karimi, Pouran
Rasta, Seyed Hossein
Sadigh-Eteghad, Saeed
Hamblin, Michael R.
Gjedde, Albert
Photobiomodulation and Coenzyme Q(10) Treatments Attenuate Cognitive Impairment Associated With Model of Transient Global Brain Ischemia in Artificially Aged Mice
title Photobiomodulation and Coenzyme Q(10) Treatments Attenuate Cognitive Impairment Associated With Model of Transient Global Brain Ischemia in Artificially Aged Mice
title_full Photobiomodulation and Coenzyme Q(10) Treatments Attenuate Cognitive Impairment Associated With Model of Transient Global Brain Ischemia in Artificially Aged Mice
title_fullStr Photobiomodulation and Coenzyme Q(10) Treatments Attenuate Cognitive Impairment Associated With Model of Transient Global Brain Ischemia in Artificially Aged Mice
title_full_unstemmed Photobiomodulation and Coenzyme Q(10) Treatments Attenuate Cognitive Impairment Associated With Model of Transient Global Brain Ischemia in Artificially Aged Mice
title_short Photobiomodulation and Coenzyme Q(10) Treatments Attenuate Cognitive Impairment Associated With Model of Transient Global Brain Ischemia in Artificially Aged Mice
title_sort photobiomodulation and coenzyme q(10) treatments attenuate cognitive impairment associated with model of transient global brain ischemia in artificially aged mice
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434313/
https://www.ncbi.nlm.nih.gov/pubmed/30983970
http://dx.doi.org/10.3389/fncel.2019.00074
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