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Photobiomodulation and Coenzyme Q(10) Treatments Attenuate Cognitive Impairment Associated With Model of Transient Global Brain Ischemia in Artificially Aged Mice
Disturbances in mitochondrial biogenesis and bioenergetics, combined with neuroinflammation, play cardinal roles in the cognitive impairment during aging that is further exacerbated by transient cerebral ischemia. Both near-infrared (NIR) photobiomodulation (PBM) and Coenzyme Q(10) (CoQ(10)) adminis...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434313/ https://www.ncbi.nlm.nih.gov/pubmed/30983970 http://dx.doi.org/10.3389/fncel.2019.00074 |
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author | Salehpour, Farzad Farajdokht, Fereshteh Mahmoudi, Javad Erfani, Marjan Farhoudi, Mehdi Karimi, Pouran Rasta, Seyed Hossein Sadigh-Eteghad, Saeed Hamblin, Michael R. Gjedde, Albert |
author_facet | Salehpour, Farzad Farajdokht, Fereshteh Mahmoudi, Javad Erfani, Marjan Farhoudi, Mehdi Karimi, Pouran Rasta, Seyed Hossein Sadigh-Eteghad, Saeed Hamblin, Michael R. Gjedde, Albert |
author_sort | Salehpour, Farzad |
collection | PubMed |
description | Disturbances in mitochondrial biogenesis and bioenergetics, combined with neuroinflammation, play cardinal roles in the cognitive impairment during aging that is further exacerbated by transient cerebral ischemia. Both near-infrared (NIR) photobiomodulation (PBM) and Coenzyme Q(10) (CoQ(10)) administration are known to stimulate mitochondrial electron transport that potentially may reverse the effects of cerebral ischemia in aged animals. We tested the hypothesis that the effects of PBM and CoQ(10), separately or in combination, improve cognition in a mouse model of transient cerebral ischemia superimposed on a model of aging. We modeled aging by 6-week administration of D-galactose (500 mg/kg subcutaneous) to mice. We subsequently induced transient cerebral ischemia by bilateral occlusion of the common carotid artery (BCCAO). We treated the mice with PBM (810 nm transcranial laser) or CoQ(10) (500 mg/kg by gavage), or both, for 2 weeks after surgery. We assessed cognitive function by the Barnes and Lashley III mazes and the What-Where-Which (WWWhich) task. PBM or CoQ(10), and both, improved spatial and episodic memory in the mice. Separately and together, the treatments lowered reactive oxygen species and raised ATP and general mitochondrial activity as well as biomarkers of mitochondrial biogenesis, including SIRT1, PGC-1α, NRF1, and TFAM. Neuroinflammatory responsiveness declined, as indicated by decreased iNOS, TNF-α, and IL-1β levels with the PBM and CoQ(10) treatments. Collectively, the findings of this preclinical study imply that the procognitive effects of NIR PBM and CoQ(10) treatments, separately or in combination, are beneficial in a model of transient global brain ischemia superimposed on a model of aging in mice. |
format | Online Article Text |
id | pubmed-6434313 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64343132019-04-12 Photobiomodulation and Coenzyme Q(10) Treatments Attenuate Cognitive Impairment Associated With Model of Transient Global Brain Ischemia in Artificially Aged Mice Salehpour, Farzad Farajdokht, Fereshteh Mahmoudi, Javad Erfani, Marjan Farhoudi, Mehdi Karimi, Pouran Rasta, Seyed Hossein Sadigh-Eteghad, Saeed Hamblin, Michael R. Gjedde, Albert Front Cell Neurosci Neuroscience Disturbances in mitochondrial biogenesis and bioenergetics, combined with neuroinflammation, play cardinal roles in the cognitive impairment during aging that is further exacerbated by transient cerebral ischemia. Both near-infrared (NIR) photobiomodulation (PBM) and Coenzyme Q(10) (CoQ(10)) administration are known to stimulate mitochondrial electron transport that potentially may reverse the effects of cerebral ischemia in aged animals. We tested the hypothesis that the effects of PBM and CoQ(10), separately or in combination, improve cognition in a mouse model of transient cerebral ischemia superimposed on a model of aging. We modeled aging by 6-week administration of D-galactose (500 mg/kg subcutaneous) to mice. We subsequently induced transient cerebral ischemia by bilateral occlusion of the common carotid artery (BCCAO). We treated the mice with PBM (810 nm transcranial laser) or CoQ(10) (500 mg/kg by gavage), or both, for 2 weeks after surgery. We assessed cognitive function by the Barnes and Lashley III mazes and the What-Where-Which (WWWhich) task. PBM or CoQ(10), and both, improved spatial and episodic memory in the mice. Separately and together, the treatments lowered reactive oxygen species and raised ATP and general mitochondrial activity as well as biomarkers of mitochondrial biogenesis, including SIRT1, PGC-1α, NRF1, and TFAM. Neuroinflammatory responsiveness declined, as indicated by decreased iNOS, TNF-α, and IL-1β levels with the PBM and CoQ(10) treatments. Collectively, the findings of this preclinical study imply that the procognitive effects of NIR PBM and CoQ(10) treatments, separately or in combination, are beneficial in a model of transient global brain ischemia superimposed on a model of aging in mice. Frontiers Media S.A. 2019-03-19 /pmc/articles/PMC6434313/ /pubmed/30983970 http://dx.doi.org/10.3389/fncel.2019.00074 Text en Copyright © 2019 Salehpour, Farajdokht, Mahmoudi, Erfani, Farhoudi, Karimi, Rasta, Sadigh-Eteghad, Hamblin and Gjedde. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Salehpour, Farzad Farajdokht, Fereshteh Mahmoudi, Javad Erfani, Marjan Farhoudi, Mehdi Karimi, Pouran Rasta, Seyed Hossein Sadigh-Eteghad, Saeed Hamblin, Michael R. Gjedde, Albert Photobiomodulation and Coenzyme Q(10) Treatments Attenuate Cognitive Impairment Associated With Model of Transient Global Brain Ischemia in Artificially Aged Mice |
title | Photobiomodulation and Coenzyme Q(10) Treatments Attenuate Cognitive Impairment Associated With Model of Transient Global Brain Ischemia in Artificially Aged Mice |
title_full | Photobiomodulation and Coenzyme Q(10) Treatments Attenuate Cognitive Impairment Associated With Model of Transient Global Brain Ischemia in Artificially Aged Mice |
title_fullStr | Photobiomodulation and Coenzyme Q(10) Treatments Attenuate Cognitive Impairment Associated With Model of Transient Global Brain Ischemia in Artificially Aged Mice |
title_full_unstemmed | Photobiomodulation and Coenzyme Q(10) Treatments Attenuate Cognitive Impairment Associated With Model of Transient Global Brain Ischemia in Artificially Aged Mice |
title_short | Photobiomodulation and Coenzyme Q(10) Treatments Attenuate Cognitive Impairment Associated With Model of Transient Global Brain Ischemia in Artificially Aged Mice |
title_sort | photobiomodulation and coenzyme q(10) treatments attenuate cognitive impairment associated with model of transient global brain ischemia in artificially aged mice |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434313/ https://www.ncbi.nlm.nih.gov/pubmed/30983970 http://dx.doi.org/10.3389/fncel.2019.00074 |
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