The discovery and characterization of K‐563, a novel inhibitor of the Keap1/Nrf2 pathway produced by Streptomyces sp

Keap1/Nrf2 pathway regulates the antioxidant stress response, detoxification response, and energy metabolism. Previous reports found that aberrant Keap1/Nrf2 pathway activation due to Kelch‐like ECH‐associated protein 1 (Keap1) mutations or Nuclear factor E2‐related factor 2 (Nrf2) mutations induced...

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Detalles Bibliográficos
Autores principales: Hori, Ran, Yamaguchi, Kozo, Sato, Hidetaka, Watanabe, Miwa, Tsutsumi, Kyoko, Iwamoto, Susumu, Abe, Masayuki, Onodera, Hideyuki, Nakamura, Satoshi, Nakai, Ryuichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434342/
https://www.ncbi.nlm.nih.gov/pubmed/30735010
http://dx.doi.org/10.1002/cam4.1949

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434342/
https://www.ncbi.nlm.nih.gov/pubmed/30735010
http://dx.doi.org/10.1002/cam4.1949

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