Isolated 5′ Signals Are an Atypical Pattern To Be Considered as Positive for ALK Rearrangement: A Brief Report of Three Cases and Review of the Literature()

Anaplastic lymphoma kinase (ALK) rearrangement is reported in 3% to 8% of patients with lung adenocarcinoma and can be detected by fluorescent in situ hybridization (FISH) or indirectly by immunohistochemistry. In FISH assay, isolated 5′ signal (loss of 3′ signal) is usually considered negative. We...

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Detalles Bibliográficos
Autores principales: Guyard, Alice, Charpy, Cécile, Théou-Anton, Nathalie, Cremades, Anne, Grassin, Frédéric, Bourgogne, Anaïs, Leroy, Karen, Pujals, Anaïs, Copie-Bergman, Christiane, Chouaid, Christos, Mansuet-Lupo, Audrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2019
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434406/
https://www.ncbi.nlm.nih.gov/pubmed/30909092
http://dx.doi.org/10.1016/j.tranon.2019.02.015

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