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Sleep disturbance among Malaysian patients with end-stage renal disease with pruritus

BACKGROUND: Chronic kidney disease-associated pruritus (CKD-aP) is a well-recognized, frequent and compromising complication among patients on hemodialysis. Despite advancement in basic medical sciences, CKD-aP is still a major complication and a challenge for both physicians and patients to manage....

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Autores principales: Rehman, Inayat Ur, Lai, Pauline Siew Mei, Lim, Soo Kun, Lee, Learn Han, Khan, Tahir Mehmood
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434782/
https://www.ncbi.nlm.nih.gov/pubmed/30909887
http://dx.doi.org/10.1186/s12882-019-1294-1
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author Rehman, Inayat Ur
Lai, Pauline Siew Mei
Lim, Soo Kun
Lee, Learn Han
Khan, Tahir Mehmood
author_facet Rehman, Inayat Ur
Lai, Pauline Siew Mei
Lim, Soo Kun
Lee, Learn Han
Khan, Tahir Mehmood
author_sort Rehman, Inayat Ur
collection PubMed
description BACKGROUND: Chronic kidney disease-associated pruritus (CKD-aP) is a well-recognized, frequent and compromising complication among patients on hemodialysis. Despite advancement in basic medical sciences, CKD-aP is still a major complication and a challenge for both physicians and patients to manage. The aim of this study was to estimate the prevalence of CKD-aP among hemodialysis patients in Malaysia, to determine the impact of CKD-aP on sleep quality and any factors associated with CKD-aP. METHOD: A multi-centered, cross-sectional study design was conducted from February 2017 to September 2017 at a tertiary hospital and its affiliated dialysis centers, in Kuala Lumpur, Malaysia. Included were patients > 18 years of age who were undergoing hemodialysis and could understand Malay. Participants were asked to fill the Malay 5D-itch scale and the Malay Pittsburgh sleep quality index (PSQI) upon recruitment. RESULTS: A total of 334/334 patients were recruited (response rate = 100%). The majority were male (59.6%) and Chinese (61.7%). A total of 61.3% had pruritus, of which most patients (63.4%) reported that their pruritus was mild. More than half (54.1%) reported that they slept > 6 h, and 93.2% experienced no sleep disturbances during the night. However; the overall PSQI median score [IQR] was 6.0 [5.0–9.0]. No significant association was found between demographic and clinical characteristics of patients with the severity of pruritus. Patients with moderate to severe pruritus were found to be 5.47 times more likely to experience poor sleep quality as compared to patients with mild or no pruritus. CONCLUSION: In Malaysia, the prevalence of CKD-aP was 61.3%, of which the majority reported that their pruritus was mild. Patients with moderate to severe pruritus were found to be 5.47 times more likely to experience poor sleep quality as compared to patients with mild or no pruritus.
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spelling pubmed-64347822019-04-08 Sleep disturbance among Malaysian patients with end-stage renal disease with pruritus Rehman, Inayat Ur Lai, Pauline Siew Mei Lim, Soo Kun Lee, Learn Han Khan, Tahir Mehmood BMC Nephrol Research Article BACKGROUND: Chronic kidney disease-associated pruritus (CKD-aP) is a well-recognized, frequent and compromising complication among patients on hemodialysis. Despite advancement in basic medical sciences, CKD-aP is still a major complication and a challenge for both physicians and patients to manage. The aim of this study was to estimate the prevalence of CKD-aP among hemodialysis patients in Malaysia, to determine the impact of CKD-aP on sleep quality and any factors associated with CKD-aP. METHOD: A multi-centered, cross-sectional study design was conducted from February 2017 to September 2017 at a tertiary hospital and its affiliated dialysis centers, in Kuala Lumpur, Malaysia. Included were patients > 18 years of age who were undergoing hemodialysis and could understand Malay. Participants were asked to fill the Malay 5D-itch scale and the Malay Pittsburgh sleep quality index (PSQI) upon recruitment. RESULTS: A total of 334/334 patients were recruited (response rate = 100%). The majority were male (59.6%) and Chinese (61.7%). A total of 61.3% had pruritus, of which most patients (63.4%) reported that their pruritus was mild. More than half (54.1%) reported that they slept > 6 h, and 93.2% experienced no sleep disturbances during the night. However; the overall PSQI median score [IQR] was 6.0 [5.0–9.0]. No significant association was found between demographic and clinical characteristics of patients with the severity of pruritus. Patients with moderate to severe pruritus were found to be 5.47 times more likely to experience poor sleep quality as compared to patients with mild or no pruritus. CONCLUSION: In Malaysia, the prevalence of CKD-aP was 61.3%, of which the majority reported that their pruritus was mild. Patients with moderate to severe pruritus were found to be 5.47 times more likely to experience poor sleep quality as compared to patients with mild or no pruritus. BioMed Central 2019-03-25 /pmc/articles/PMC6434782/ /pubmed/30909887 http://dx.doi.org/10.1186/s12882-019-1294-1 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Rehman, Inayat Ur
Lai, Pauline Siew Mei
Lim, Soo Kun
Lee, Learn Han
Khan, Tahir Mehmood
Sleep disturbance among Malaysian patients with end-stage renal disease with pruritus
title Sleep disturbance among Malaysian patients with end-stage renal disease with pruritus
title_full Sleep disturbance among Malaysian patients with end-stage renal disease with pruritus
title_fullStr Sleep disturbance among Malaysian patients with end-stage renal disease with pruritus
title_full_unstemmed Sleep disturbance among Malaysian patients with end-stage renal disease with pruritus
title_short Sleep disturbance among Malaysian patients with end-stage renal disease with pruritus
title_sort sleep disturbance among malaysian patients with end-stage renal disease with pruritus
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434782/
https://www.ncbi.nlm.nih.gov/pubmed/30909887
http://dx.doi.org/10.1186/s12882-019-1294-1
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