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High prevalence of Pfdhfr–Pfdhps quadruple mutations associated with sulfadoxine–pyrimethamine resistance in Plasmodium falciparum isolates from Bioko Island, Equatorial Guinea

BACKGROUND: Sulfadoxine–pyrimethamine (SP) is recommended for intermittent preventive treatment of malaria in Africa. However, increasing SP resistance (SPR) affects the therapeutic efficacy of the SP. As molecular markers, Pfdhfr (dihydrofolate reductase) and Pfdhps (dihydropteroate synthase) genes...

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Detalles Bibliográficos
Autores principales:	Jiang, Tingting, Chen, Jiangtao, Fu, Hongxia, Wu, Kai, Yao, Yi, Eyi, Juan Urbano Monsuy, Matesa, Rocio Apicante, Obono, Maximo Miko Ondo, Du, Weixing, Tan, Huabing, Lin, Min, Li, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434785/ https://www.ncbi.nlm.nih.gov/pubmed/30914041 http://dx.doi.org/10.1186/s12936-019-2734-x

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