Essential roles of EphrinB2 in mammalian heart: from development to diseases

EphrinB2, a membrane-tethered ligand preferentially binding to its receptor EphB4, is ubiquitously expressed in all mammals. Through the particular bidirectional signaling, EphrinB2 plays a critical role during the development of cardiovascular system, postnatal angiogenesis physiologically and path...

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Autores principales: Su, Sheng-an, Xie, Yao, Zhang, Yuhao, Xi, Yutao, Cheng, Jie, Xiang, Meixiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434800/
https://www.ncbi.nlm.nih.gov/pubmed/30909943
http://dx.doi.org/10.1186/s12964-019-0337-3
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author Su, Sheng-an
Xie, Yao
Zhang, Yuhao
Xi, Yutao
Cheng, Jie
Xiang, Meixiang
author_facet Su, Sheng-an
Xie, Yao
Zhang, Yuhao
Xi, Yutao
Cheng, Jie
Xiang, Meixiang
author_sort Su, Sheng-an
collection PubMed
description EphrinB2, a membrane-tethered ligand preferentially binding to its receptor EphB4, is ubiquitously expressed in all mammals. Through the particular bidirectional signaling, EphrinB2 plays a critical role during the development of cardiovascular system, postnatal angiogenesis physiologically and pathologically, and cardiac remodeling after injuries as an emerging role. This review highlights the pivotal involvement of EphrinB2 in heart, from developmental cardiogenesis to pathological cardiac remodeling process. Further potential translational therapies will be discussed in targeting EphrinB2 signaling, to better understand the prevention and treatment of cardiovascular diseases.
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spelling pubmed-64348002019-04-08 Essential roles of EphrinB2 in mammalian heart: from development to diseases Su, Sheng-an Xie, Yao Zhang, Yuhao Xi, Yutao Cheng, Jie Xiang, Meixiang Cell Commun Signal Review EphrinB2, a membrane-tethered ligand preferentially binding to its receptor EphB4, is ubiquitously expressed in all mammals. Through the particular bidirectional signaling, EphrinB2 plays a critical role during the development of cardiovascular system, postnatal angiogenesis physiologically and pathologically, and cardiac remodeling after injuries as an emerging role. This review highlights the pivotal involvement of EphrinB2 in heart, from developmental cardiogenesis to pathological cardiac remodeling process. Further potential translational therapies will be discussed in targeting EphrinB2 signaling, to better understand the prevention and treatment of cardiovascular diseases. BioMed Central 2019-03-25 /pmc/articles/PMC6434800/ /pubmed/30909943 http://dx.doi.org/10.1186/s12964-019-0337-3 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Su, Sheng-an
Xie, Yao
Zhang, Yuhao
Xi, Yutao
Cheng, Jie
Xiang, Meixiang
Essential roles of EphrinB2 in mammalian heart: from development to diseases
title Essential roles of EphrinB2 in mammalian heart: from development to diseases
title_full Essential roles of EphrinB2 in mammalian heart: from development to diseases
title_fullStr Essential roles of EphrinB2 in mammalian heart: from development to diseases
title_full_unstemmed Essential roles of EphrinB2 in mammalian heart: from development to diseases
title_short Essential roles of EphrinB2 in mammalian heart: from development to diseases
title_sort essential roles of ephrinb2 in mammalian heart: from development to diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434800/
https://www.ncbi.nlm.nih.gov/pubmed/30909943
http://dx.doi.org/10.1186/s12964-019-0337-3
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